KKII5 - Moligand™,≥98% , CAS No.6381-55-1

CAS: 6381-55-1 Cat. No.: K649315 分子式: C₁₆H₁₄N₂S 分子量: 266.36 PubChem CID: 2725891

GRADE & PURITY Moligand™, ≥98%

Synonyms

4,6-Diphenyl-1,2,3,4-Tetrahydropyrimidine-2-Thione | 4,6-Diphenyl-3,4-dihydropyrimidine-2(1H)-thione

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

KKII5 is a potent Lipoxygenase ( LOX-1 ) inhibitor with an IC 50 of 19 μM. KKII5 inhibits lipid peroxidation

In Vitro

KKII5 interacts with HIS499 of the cavity by forming one π–π stacking interaction between the phenyl ring of the molecule and the imidazole ring of HIS499. KKII5 (100 μM) strongly inhibits lipid peroxidation with 98% inhibition. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 19 μM (LOX-1)

Specifications

同義語

4,6-Diphenyl-1,2,3,4-Tetrahydropyrimidine-2-Thione | 4,6-Diphenyl-3,4-dihydropyrimidine-2(1H)-thione

仕様と純度

Moligand™,≥98%

生化学的・生理学的メカニズム

KKII5 is a potent Lipoxygenase ( LOX-1 ) inhibitor with an IC 50 of 19 μM. KKII5 inhibits lipid peroxidation.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• 異性体SMILES: C1=CC=C(C=C1)C2C=C(NC(=S)N2)C3=CC=CC=C3
• PubChem CID: 2725891
• 分子量: 266.36

化学的性質と物理的性質

• 分子量: 266.400 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 266.088 Da
• Monoisotopic Mass: 266.088 Da
• Topological Polar Surface Area: 56.200 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 352.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1