Koumine - ≥98% , CAS No.1358-76-5

CAS: 1358-76-5 Cat. No.: K418590 分子式: C₂₀H₂₂N₂O 分子量: 306.4 EC番号: 111-893-2

GRADE & PURITY ≥98%

Synonyms

(3S,4S,4aR,6R,11bS,11cS)-11c-Ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4 | CID 91895267

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Koumine can induce apoptosis of LoVo cells in a time-dependent manner and inhibit the DNA synthesis in LoVo cells, thereby blocking the cell cycle from G1 to S phase. Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has therapeutic effect against psoriasis, which is related to the inhibition of epidermal cell proliferation, promoting the formation of granular cells and decreasing the serum level of IL- Koumine can significantly reduce the damage to axon and myelin sheath of the sciatic nerve and increase sensory nerve conduction velocity , without affecting body weight and blood glucose, these findings encourage the use of koumine in the treatment of diabetic neuropathy. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. Koumine may produce anxiolytic-effect by increasing the levels of pregnenolone and allopregnenolone in hippocampus.

Specifications

同義語

(3S,4S,4aR,6R,11bS,11cS)-11c-Ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4 | CID 91895267

仕様と純度

≥98%

保管条件

Protected from light,Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

製品の性質

ALogP

1.879

hba_count

2

回転可能な結合

1

名前と識別子

パブケム・シド

488202539

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/488202539

カノニカル・スマイル

CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C

IUPAC Name

(1R,10R,12S,15S,16R,17S)-15-ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene

InChIKey

VTLYEMHGPMGUOT-FXWNUWCSSA-N

INCHI

1S/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/m0/s1

異性体SMILES

CN1C[C@]2([C@@H]3C[C@@H]4C5=NC6=CC=CC=C6[C@]52C[C@H]1[C@H]3CO4)C=C

分子量

306.4

Reaxy-Rn

25328208

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25328208&ln=

化学的性質と物理的性質

• 溶解度: DMSO: 2 mg/mL, clear (Warmed)
• 感度: Light sensitive;Moisture sensitive
• DMSO（mg / mL） 最大溶解度: 15
• DMSO（mM） 最大溶解度: 48.9553771084918

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1358-76-5, the molecular formula is C20H22N2O, and the molecular weight is 306.4 g/mol. InChIKey VTLYEMHGPMGUOT-FXWNUWCSSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.