L-372662 - 10mM in DMSO , CAS No.162045-26-3

CAS: 162045-26-3 Cat. No.: L654535 分子式: C₃₃H₃₈N₄O₆ 分子量: 586.68 PubChem CID: 5311202

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

L-372662 is a potent and orally active non-peptide oxytocin antagonist with a K i value of 4.8. The K d value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V 1a R

In Vivo

L-372662 is an antagonist of oxytocin-induced uterine contractions in late gestation pregnant rhesus monkeys (AD50 = 36 micrograms/kg), oral bioavailability (F = 90% in dogs), and aqueous solubility (10 mg/mL). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Ki: 4.8 (oxytocin)

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

L-372662 is a potent and orally active non-peptide oxytocin antagonist with a K i value of 4.8. The K d value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V 1a R.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ANTAGONIST

名前と識別子

異性体SMILES

CC1=C(C=CC=[N+]1[O-])CN2CCC(CC2)OC3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5C6=CC=CC=C6COC5=O)OC

代替CAS番号

162045-26-3

PubChem CID

5311202

MeSH用語

1-(1-4-(1-(2-methyl-1-oxidopridin-3-ylmetyhl)piperidin-4-yloxyl-2-methoxybenzoyl)piperidin-4-yl)-1,4-dihydrobenz(d)(1,3)oxazin-2-one;L 372662;L-372662

分子量

586.68

関連ターゲット（人間）

OXTR Tclin Oxytocin receptor (0 Activities)

Discover Target: OXTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 162045-26-3, the molecular formula is C33H38N4O6, and the molecular weight is 586.68 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.