≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
概要
Application
Lalistat 2 has been used as a lysosomal acid lipase (LAL) inhibitor to study its effects on hypoxia-inducible factor (HIF) in mice. It has also been used as a LAL inhibitor to study LAL activity on dried blood spot cards.
Selective lysosomal acid lipase inhibitor (IC50= 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).Lalistat-2 is a potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa).
This compound belongs to the class of organic compounds known as piperidinecarboxylic acids. These are compounds containing a piperidine ring which bears a carboxylic acid group.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Solvent:DMSO, Max Conc. mg/mL: 29.64, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 29.64, Max Conc. mM: 100
分子量
296.390 g/mol
XLogP3
2.600
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
3
Exact Mass
296.131 Da
Monoisotopic Mass
296.131 Da
Topological Polar Surface Area
86.800 Ų
Heavy Atom Count
20
Formal Charge
0
Complexity
332.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
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よくある質問
What is the purity of this product?
This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1234569-09-5, the molecular formula is C??H??N?O?S, and the molecular weight is 296.39 g/mol. InChIKey PNYYVHOTXOEBEV-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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