Lazabemide - Moligand™, ≥98% , Inhibitor of Monoamine oxidase B, CAS No.103878-84-8, Inhibitor of Monoamine oxidase B

CAS: 103878-84-8 Cat. No.: L418544 分子式: C₈H₁₀ClN₃O 分子量: 199.64

GRADE & PURITY Moligand™, ≥98%

Synonyms

5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl)-amide | LAZABEMIDE [USAN] | 2-Pyridinecarboxamide, N-(2-aminoethyl)-5-chloro- | JZXRLKWWVNUZRB-UHFFFAOYSA-N | MS-23081 | n-(2-aminoethyl)-5-chloro-2-pyridinecarboxamide | N-(2-Aminoethyl)-5-chloro-2-pyri

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Lazabemide is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM.

Specifications

同義語

5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl)-amide | LAZABEMIDE [USAN] | 2-Pyridinecarboxamide, N-(2-aminoethyl)-5-chloro- | JZXRLKWWVNUZRB-UHFFFAOYSA-N | MS-23081 | n-(2-aminoethyl)-5-chloro-2-pyridinecarboxamide | N-(2-Aminoethyl)-5-chloro-2-pyri

仕様と純度

Moligand™, ≥98%

生化学的・生理学的メカニズム

Lazabemide (Ro 19-6327) is a selective and reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM), but less active against MAO-A (IC50>100 μM). High concentrations of Lazabemide have inhibitory effects on monoamine uptake, with IC50 values ​​o

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of Monoamine oxidase B

純度

≥98%

製品の性質

• ALogP: 0.533
• hba_count: 2
• HBD数: 2
• 回転可能な結合: 3

名前と識別子

• パブケム・シド: 528771933
• カノニカル・スマイル: C1=CC(=NC=C1Cl)C(=O)NCCN
• IUPAC Name: N-(2-aminoethyl)-5-chloropyridine-2-carboxamide
• InChIKey: JZXRLKWWVNUZRB-UHFFFAOYSA-N
• INCHI: 1S/C8H10ClN3O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10/h1-2,5H,3-4,10H2,(H,11,13)
• 異性体SMILES: C1=CC(=NC=C1Cl)C(=O)NCCN
• 分子量: 199.64
• Reaxy-Rn: 6646689
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6646689&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 分類 Pyridines and derivatives
      • Subclass Pyridinecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 分類: Pyridines and derivatives
• Subclass: Pyridinecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridinecarboxamides
• Alternative Parents: 2-heteroaryl carboxamides Aryl chlorides Heteroaromatic compounds Secondary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organochlorides Organic oxides Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridinecarboxamide - 2-heteroaryl carboxamide - Aryl chloride - Aryl halide - Heteroaromatic compound - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Primary aliphatic amine - Amine - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as pyridinecarboxamides. These are compounds containing a pyridine ring bearing a carboxamide.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

MAOB Tclin Amine oxidase [flavin-containing] B (26 Activities)

Discover Target: MAOB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOB Tclin Monoamine oxidase B (8835 Activities)

Discover Target: MAOB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

関連ターゲット（非人間）

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Maob Monoamine oxidase (439 Activities)

Discover Target: Maob

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• DMSO（mg / mL） 最大溶解度: 40
• DMSO（mM） 最大溶解度: 169.419737399407
• 水（mg / mL） 最大溶解度: 40
• 水（mM） 最大溶解度: 169.419737399407
• 分子量: 199.640 g/mol
• XLogP3: 0.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 199.051 Da
• Monoisotopic Mass: 199.051 Da
• Topological Polar Surface Area: 68.000 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 177.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1