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liarozole - Moligand™, ≥98% , Inhibitor of CYP26A1, CAS No.115575-11-6, Inhibitor of CYP26A1

CAS: 115575-11-6 Cat. No.: L611529 分子式: C17H13ClN4 分子量: 308.76
COA
liarozole - Moligand™, ≥98% , Inhibitor of CYP26A1, CAS No.115575-11-6, Inhibitor of CYP26A1
注文可能
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
UNII-K0Q29TGV9Y | UGFHIPBXIWJXNA-UHFFFAOYSA-N | 5-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-benzimidazole | CHEBI:135316 | F81706 | R 085246 | R-61405 | 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)- | Liarozolum | BDBM50157605 | 1H-Be
Storage
Store at 2-8°C,Protected from light,Argon charged,Desiccated
Shipped In
Wet ice
★
Size
USA
ドイツ (EU)*
Price
Qty
1mg
L611529-1mg
受注生産 · 8～12週間
$49.90
5mg
L611529-5mg
受注生産 · 8～12週間
$116.90
25mg
L611529-25mg
受注生産 · 8～12週間
$369.90
100mg
L611529-100mg
受注生産 · 8～12週間
$939.90
Enter a quantity for the sizes you want to add.
Bulk / Custom
♡ ウィッシュリスト ⇅ 比較リストに入れる ⎙ Print page
SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
概要 Specifications 名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造 関連ターゲット（人間） 関連ターゲット（非人間） 作用メカニズム 証明書（CoA、COO、BSE/TSEと分析図） 化学的性質と物理的性質 よくある質問と記事 ソリューション計算機 レビュー
🧪
Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Protected from light,Argon charged,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

Liarozole is an imidazole derivative and a retinoic acid (RA) metabolism blocker (RAMBA) with antitumor activity. It inhibits retinoic acid-dependent cytochrome P450 (CYP26) 4-hydroxylation (IC50 = 7 μM), leading to increased tissue retinoic acid levels.

Specifications

同義語
UNII-K0Q29TGV9Y | UGFHIPBXIWJXNA-UHFFFAOYSA-N | 5-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-benzimidazole | CHEBI:135316 | F81706 | R 085246 | R-61405 | 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)- | Liarozolum | BDBM50157605 | 1H-Be
仕様と純度
Moligand™, ≥98%
保管条件
Store at 2-8°C,Protected from light,Argon charged,Desiccated
入荷
Wet ice
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
等級
Moligand™
アクションタイプ
INHIBITOR
作用メカニズム
Inhibitor of CYP26A1
純度
≥98%
名前と識別子
カノニカル・スマイル
C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4
IUPAC Name
6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole
InChIKey
UGFHIPBXIWJXNA-UHFFFAOYSA-N
INCHI
1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)
異性体SMILES
C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4
代替CAS番号
172282-43-8,115575-11-6,171849-18-6,145858-52-2 (fumarate)
MeSH用語
liarozole;liarozole fumarate;liarozole monohydrochloride;Liazal;R 085246;R 61405;R 75251;R-085246;R-61405;R-75251;R085246
分子量
308.76

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
分類Benzimidazoles
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentBenzimidazoles
Alternative Parents Chlorobenzenes  N-substituted imidazoles  Aryl chlorides  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Benzimidazole - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Azole - Imidazole - Heteroaromatic compound - Azacycle - Organohalogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Organochloride - Organonitrogen compound - Aromatic heteropolycyclic compound
説明This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
External Descriptors Not available
3 D構造
インタラクティブ化学構造モデル





関連ターゲット（人間）
CYP26A1 Tchem Cytochrome P450 26A1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP24A1 Tchem 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP26B1 Tchem Cytochrome P450 26B1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP19A1 Tclin Aromatase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP19A1 Tclin Cytochrome P450 19A1 (6099 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NB-4 (999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP26A1 Tchem Cytochrome P450 26A1 (308 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsomes (16955 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP26B1 Tchem Cytochrome P450 26B1 (25 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
関連ターゲット（非人間）
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cyp24a1 Cytochrome P450 24A1 (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
作用メカニズム
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
化学的性質と物理的性質
感度light sensitive
分子量308.800 g/mol
XLogP33.500
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass308.083 Da
Monoisotopic Mass308.083 Da
Topological Polar Surface Area46.500 Ų
Heavy Atom Count22
Formal Charge0
Complexity380.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
よくある質問と記事
Mechanisms of Retinol Action in the Skin: From Metabolic Activation and RAR/RXR-Mediated Transcriptional Regulation to Epidermal Renewal and Collagen Homeostasis
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Retinol
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View related series

CYP26A1 Inhibitor (4) Lipid Metabolism (4988)

関連商品

Liarozole - Moligand™, 10 mM in DMSO , CAS No.115575-11-6
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