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LJI308 - ≥98%以上(HPLC) , CAS No.1627709-94-7

CAS: 1627709-94-7 Cat. No.: L287303 分子式: C21H18F2N2O2 分子量: 368.38
COA
LJI308 - ≥98%以上(HPLC) CAS No(1627709-94-7) by Aladdin Scientific
注文可能
GRADE & PURITY ≥98%(HPLC)
Synonyms
2,6-ジフルオロ-4-[4-[4-(4-モルホリニル)フェニル]-3-ピリジニル]フェノール｜2,6-ジフルオロ-4-(4-(4-モルホリノフェニル)ピリジン-3-イル)フェノール
Storage
20℃で保存
Shipped In
アイスチェスト＋アイスパッド
★
Size
USA
ドイツ (EU)*
Price
Qty
1mg
L287303-1mg
受注生産 · 8～12週間
$40.90
5mg
L287303-5mg
2 在庫あり
—

$143.90

$215.90
保存 $72.00 (33.35%)
10mg
L287303-10mg
3 在庫あり
—

$250.90

$376.90
保存 $126.00 (33.43%)
25mg
L287303-25mg
2 在庫あり
—

$548.90

$823.90
保存 $275.00 (33.38%)
50mg
L287303-50mg
1 在庫あり
—

$988.90

$1,483.90
保存 $495.00 (33.36%)
100mg
L287303-100mg
1 在庫あり
—

$1,778.90

$2,668.90
保存 $890.00 (33.35%)
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
概要 Specifications 名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造 関連ターゲット（人間） 関連ターゲット（非人間） 作用メカニズム 証明書（CoA、COO、BSE/TSEと分析図） 化学的性質と物理的性質 よくある質問と記事 ソリューション計算機 レビュー
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Why this grade

≥98%以上(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

20℃で保存 Ships アイスチェスト＋アイスパッド Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

製品応用：LJI308

LJI308は強力な汎リボソームS6キナーゼ（RSK）阻害剤であり、RSK1、RSK2、RSK3に対するIC50はそれぞれ6 nM、4 nM、13 nMである。LJI308は、放射線照射後、EGF処理後、およびKRAS変異を発現している細胞において、RSK（T359/S363）およびYB-1（S102）のリン酸化を阻害する。

Specifications

同義語
2,6-ジフルオロ-4-[4-[4-(4-モルホリニル)フェニル]-3-ピリジニル]フェノール｜2,6-ジフルオロ-4-(4-(4-モルホリノフェニル)ピリジン-3-イル)フェノール
仕様と純度
≥98%以上(HPLC)
生化学的・生理学的メカニズム
強力な汎リボソームS6プロテインキナーゼ（RSK）阻害剤（IC50値は4～13 nM）。他のキナーゼよりもRSKアイソフォームに選択性を示す。試験管内でRSK依存性のY-box binding protein 1 (YB-1)のリン酸化を阻害する。トリプルネガティブ細胞の増殖を抑制
保管条件
20℃で保存
入荷
アイスチェスト＋アイスパッド
純度
≥98%(HPLC)
名前と識別子
パブケム・シド504772886
パブケム・シド・ウルhttps://pubchem.ncbi.nlm.nih.gov/substance/504772886
カノニカル・スマイルC1COCCN1C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(C(=C4)F)O)F
IUPAC Name2,6-difluoro-4-[4-(4-morpholin-4-ylphenyl)pyridin-3-yl]phenol
InChIKeyYUYJEQHNWKQNBT-UHFFFAOYSA-N
INCHI1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2
異性体SMILES C1COCCN1C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(C(=C4)F)O)F
分子量 368.38
Reaxy-Rn 28553523
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28553523&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
分類Oxazinanes
SubclassMorpholines
Intermediate Tree Nodes Not available
Direct ParentPhenylmorpholines
Alternative Parents Phenylpyridines  O-fluorophenols  Dialkylarylamines  Aniline and substituted anilines  Fluorobenzenes  Aryl fluorides  Heteroaromatic compounds  Oxacyclic compounds  Dialkyl ethers  Azacyclic compounds  Organopnictogen compounds  Organofluorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Phenylmorpholine - 3-phenylpyridine - 4-phenylpyridine - 2-halophenol - 2-fluorophenol - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Phenol - Fluorobenzene - Halobenzene - Aryl halide - Benzenoid - Aryl fluoride - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Tertiary amine - Oxacycle - Azacycle - Dialkyl ether - Ether - Hydrocarbon derivative - Amine - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Aromatic heteromonocyclic compound
説明This compound belongs to the class of organic compounds known as phenylmorpholines. These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond.
External Descriptors Not available
3 D構造
インタラクティブ化学構造モデル





関連ターゲット（人間）
RPS6KA1 Tchem Ribosomal protein S6 kinase alpha-1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RPS6KA2 Tchem Ribosomal protein S6 kinase alpha-2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RPS6KA3 Tchem Ribosomal protein S6 kinase alpha-3 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA1 Tchem Ribosomal protein S6 kinase alpha 1 (2796 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA6 Tchem Ribosomal protein S6 kinase alpha 6 (2027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA2 Tchem Ribosomal protein S6 kinase alpha 2 (2184 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA3 Tchem Ribosomal protein S6 kinase alpha 3 (4284 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
関連ターゲット（非人間）
Rps6ka3 Ribosomal protein S6 kinase alpha-3 (39 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
作用メカニズム
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate Type日付商品
H23031001Certificate of AnalysisMay 18, 2026 L287303
H23031004Certificate of AnalysisMay 18, 2026 L287303
H23031005Certificate of AnalysisMay 18, 2026 L287303
H23031006Certificate of AnalysisMay 18, 2026 L287303
H23031008Certificate of AnalysisMay 18, 2026 L287303
H23031022Certificate of AnalysisMay 18, 2026 L287303
H2303986Certificate of AnalysisMay 18, 2026 L287303
H2303987Certificate of AnalysisMay 18, 2026 L287303
H2303991Certificate of AnalysisMay 18, 2026 L287303
H2303993Certificate of AnalysisMay 18, 2026 L287303
K2525173Certificate of AnalysisJul 17, 2023 L287303
化学的性質と物理的性質
溶解度DMSO:10 mg/mL,warmed；H2O:Insoluble
分子量368.400 g/mol
XLogP33.700
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass368.134 Da
Monoisotopic Mass368.134 Da
Topological Polar Surface Area45.600 Ų
Heavy Atom Count27
Formal Charge0
Complexity457.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
よくある質問と記事
MAPK/ERK Signaling Pathway: RAS–RAF–MEK–ERK Cascade Regulation, Cellular Functional Outputs, and Research Tool Applications
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
FGF EGF PDGF ERK1 MAPK3 ERK2 MAPK1
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