LM22A-4 - ≥98% , CAS No.37988-18-4

CAS: 37988-18-4 Cat. No.: L276057 分子式: C₁₅H₂₁N₃O₆ 分子量: 339.34

GRADE & PURITY ≥98%

Synonyms

LM 22A4 | LM22a4 | LM-22A4 | LM22A-4 | N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | 5GCL3P6AF5 | N,N',N''-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | SCHEMBL3321012 | 1,3,5-B

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Shipped at room temperature. Store at -20°C.

Application

LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates.

Specifications

同義語

LM 22A4 | LM22a4 | LM-22A4 | LM22A-4 | N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | 5GCL3P6AF5 | N,N',N''-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | SCHEMBL3321012 | 1,3,5-B

仕様と純度

≥98%

生化学的・生理学的メカニズム

Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB, activating TrkB signaling. Displaces BDNF (IC 50 = 47 nM) in binding assays.\xa0Prevents neuronal degeneration with equal efficacy to that of BDNF in in vitro models of

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

注

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

純度

≥98%

名前と識別子

パブケム・シド

504760670

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/504760670

カノニカル・スマイル

C1=C(C=C(C=C1C(=O)NCCO)C(=O)NCCO)C(=O)NCCO

IUPAC Name

1-N,3-N,5-N-tris(2-hydroxyethyl)benzene-1,3,5-tricarboxamide

InChIKey

RGWJKANXFYJKHN-UHFFFAOYSA-N

INCHI

1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)

異性体SMILES

C1=C(C=C(C=C1C(=O)NCCO)C(=O)NCCO)C(=O)NCCO

分子量

339.34

Reaxy-Rn

2398310

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2398310&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzamides
• Alternative Parents: N-acylethanolamines Benzoyl derivatives Secondary carboxylic acid amides Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzamide - Benzoyl - N-acylethanolamine - Carboxamide group - Secondary carboxylic acid amide - Alkanolamine - Carboxylic acid derivative - Alcohol - Organooxygen compound - Organonitrogen compound - Primary alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic homomonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as benzamides. These are organic compounds containing a carboxamido substituent attached to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（非人間）

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: H2O: 2 mg/mL, clear (warmed)
• 分子量: 339.340 g/mol
• XLogP3: -2.300
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 339.143 Da
• Monoisotopic Mass: 339.143 Da
• Topological Polar Surface Area: 148.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 358.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 37988-18-4, the molecular formula is C15H21N3O6, and the molecular weight is 339.34 g/mol. InChIKey RGWJKANXFYJKHN-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.