Lomustine - Moligand™, 10mM in DMSO , DNA inhibitor, CAS No.13010-47-4, DNA inhibitor

CAS: 13010-47-4 Cat. No.: L409232 分子式: C₉H₁₆ClN₃O₂ 分子量: 233.7 EC番号: 235-859-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC79037, Gleostine, CeeNU, CCNU | N-​(2-​chloroethyl)​-​N'-​cyclohexyl-​N-​nitroso-urea

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging theDNAand stops cells from dividing.
In vitro

Lomustine inhibits the growth of ZR-75-1 and U373 with IC50 of 12 μM and 15 μM, respectively. Lomustine reduces the level of expression of the DNA repair protein O6-alkylguanine-DNA alkyltransferase. Lomustine (420 μM) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2/M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells.

In vivo

Lomustine can cause delayed, cumulative dose-related, chronic hepatotoxicity that is irreversible and can be fatal. Lomustine could result in infrequent severe hematological toxicity in cats with spontaneously arising tumors, and the incidence of either grade III or IV neutropenia and thrombocytopenia is 4.1% and 1.0%, respectively. Lomustine trends toward a greater likelihood for progressive neutropenia and statistically significant higher response rates in cats with spontaneously arising tumors.
Cell Data

cell lines：A375 cells

Concentrations：133 μM

Incubation Time：1 hour

Powder Purity:≥98%

Specifications

同義語

NSC79037, Gleostine, CeeNU, CCNU | N-​(2-​chloroethyl)​-​N'-​cyclohexyl-​N-​nitroso-urea

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

DNA inhibitor

製品の性質

• ALogP: 2.8

名前と識別子

• 異性体SMILES: C1CCC(CC1)NC(=O)N(CCCl)N=O
• WGKドイツ: 3
• RTECS: YS4900000
• 分子量: 233.7
• Reaxy-Rn: 2125058
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2125058&ln=

化学的性質と物理的性質

• 融点（°C）: 89.0-93.0°C

参考文献

1. Maryam H. Alaayedi, Nidhal K. Maraie.  (2023)  Lomustine’s nanoemulsion as nose-to-brain drug delivery system for CNS tumor treatment.  SAUDI PHARMACEUTICAL JOURNAL,      [PMID:37457367] [10.1016/j.jsps.2023.06.025]

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 13010-47-4, the molecular formula is C9H16ClN3O2, and the molecular weight is 233.7 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.