Lonapalene - Moligand™,≥98% , CAS No.91431-42-4

CAS: 91431-42-4 Cat. No.: L646394 分子式: C16H15ClO6 分子量: 338.74 PubChem CID: 56237
注文可能
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
Lonapalene [USAN:INN] | MS-25159 | 6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate | Lonapalene [USAN] | D04770 | LONAPALENE [MART.] | Lonapaleno [Spanish] | Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-naphthalen-1-yl ester (Ionapalene) | LONAPALENE
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Size
USA
ドイツ (EU)*
Price
Qty
1mg
L646394-1mg
受注生産 · 8~12週間
$101.90
5mg
L646394-5mg
受注生産 · 8~12週間
$306.90
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

Lonapalene (RS4317) is a topically effective 5-lipoxygenase ( 5-LO ) inhibitor.

In Vitro

Lonapalene (RS4317) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:5-LO

Specifications

同義語
Lonapalene [USAN:INN] | MS-25159 | 6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate | Lonapalene [USAN] | D04770 | LONAPALENE [MART.] | Lonapaleno [Spanish] | Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-naphthalen-1-yl ester (Ionapalene) | LONAPALENE
仕様と純度
Moligand™, ≥98%
生化学的・生理学的メカニズム
Lonapalene (RS4317) is a topically effective 5-lipoxygenase ( 5-LO ) inhibitor.
保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
等級
Moligand™
アクションタイプ
INHIBITOR
純度
≥98%
名前と識別子
カノニカル・スマイル
CC(=O)OC1=C(C(=C(C2=C1C=CC(=C2)Cl)OC(=O)C)OC)OC
IUPAC Name
(4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate
InChIKey
IFWMVQUGSGWCRP-UHFFFAOYSA-N
INCHI
1S/C16H15ClO6/c1-8(18)22-13-11-6-5-10(17)7-12(11)14(23-9(2)19)16(21-4)15(13)20-3/h5-7H,1-4H3
異性体SMILES
CC(=O)OC1=C(C(=C(C2=C1C=CC(=C2)Cl)OC(=O)C)OC)OC
代替CAS番号
91431-42-4
PubChem CID
56237
MeSH用語
6-chloro-2,3-dimethoxynaphthalene-1,4-diol diacetate;lonapalene;RS 43179;RS-43179
分子量
338.74

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
分類Naphthalenes
SubclassChloronaphthalenes
Intermediate Tree Nodes Not available
Direct ParentChloronaphthalenes
Alternative Parents Anisoles  Alkyl aryl ethers  Dicarboxylic acids and derivatives  Aryl chlorides  Carboxylic acid esters  Organochlorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic homopolycyclic compounds
Substituents Chloronaphthalene - Anisole - Alkyl aryl ether - Aryl chloride - Aryl halide - Dicarboxylic acid or derivatives - Carboxylic acid ester - Ether - Carboxylic acid derivative - Organohalogen compound - Carbonyl group - Organic oxide - Organic oxygen compound - Organochloride - Organooxygen compound - Hydrocarbon derivative - Aromatic homopolycyclic compound
説明This compound belongs to the class of organic compounds known as chloronaphthalenes. These are aromatic heterocyclic compounds containing a naphthalene moiety substituted at one or more positions by a chlorine atom.
External Descriptors Not available
3 D構造
インタラクティブ化学構造モデル





関連ターゲット(人間)
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Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
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Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
関連ターゲット(非人間)
PLA2G1B Phospholipase A2 group 1B (227 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
作用メカニズム
証明書(CoA、COO、BSE/TSEと分析図)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
化学的性質と物理的性質
溶解度DMSO : 100 mg/mL (295.21 mM; Need ultrasonic)
感度Moisture sensitive
分子量338.740 g/mol
XLogP33.200
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass338.056 Da
Monoisotopic Mass338.056 Da
Topological Polar Surface Area71.100 Ų
Heavy Atom Count23
Formal Charge0
Complexity442.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
ソリューション計算機
レビュー

顧客レビュー

よくある質問

What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 91431-42-4, the molecular formula is C16H15ClO6, and the molecular weight is 338.74 g/mol. InChIKey IFWMVQUGSGWCRP-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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