LP-211 - 10mM in DMSO , CAS No.1052147-86-0

CAS: 1052147-86-0 Cat. No.: L656330 分子式: C₃₀H₃₄N₄O 分子量: 466.63 PubChem CID: 25107716

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

LP-211 is a selective and blood−brain barrier penetrant 5-HT 7 receptor agonist, with a K i of 0.58 nM, with high selectivity over 5-HT 1A receptor (K i , 188 nM) and D 2 receptor (K i , 142 nM).

In Vitro

LP-211 is a selective 5-HT 7 receptor agonist, with a K i of 0.58 nM, 324- and 245-fold selectivity over 5-HT 1A receptor (K i , 188 nM) and D 2 receptor (K i , 142 nM). LP-211 shows agonist properties with an EC 50 of 0.6 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LP-211 (10 mg/kg, i.p.) rapidly reaches the systemic circulation in the mouse, with mean C max of 0.76 ± 0.32 μg/mL at 30 min . LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by SB-269970. LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:5-HT 7 Receptor 0.58 nM (Ki) 5-HT 1A Receptor 188 nM (Ki) D 2 Receptor 142 nM (Ki)

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

LP-211 is a selective and blood−brain barrier penetrant 5-HT 7 receptor agonist, with a K i of 0.58 nM, with high selectivity over 5-HT 1A receptor (K i , 188 nM) and D 2 receptor (K i , 142 nM).

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

AGONIST

名前と識別子

異性体SMILES

C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4

PubChem CID

25107716

分子量

466.63

関連ターゲット（人間）

DRD2 Tclin D(2) dopamine receptor (0 Activities)

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR7 Tclin 5-hydroxytryptamine receptor 7 (7 Activities)

Discover Target: HTR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A (0 Activities)

Discover Target: HTR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1052147-86-0, the molecular formula is C30H34N4O, and the molecular weight is 466.63 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.