LTV-1 - 10mM in DMSO , CAS No.347379-29-7

CAS: 347379-29-7 Cat. No.: L656738 Molecular Weight: 472.51 EC Number: 803-585-8 PubChem CID: 1920999

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

LTV-1 is a potent lymphoid tyrosine phosphatase ( LYP ) inhibitor in T cells with an IC 50 of 508 nM. LTV-1 has the potential for autoimmunity treatment

In Vitro

LTV-1 (1.25-40 μM) has no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). Thus, LTV-1 is not cytotoxic in HeLa cells, Jurkat TAg T cells and peripheral blood mononuclear cells (PBMC). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HeLa cells, Jurkat TAg T cells, and PBMC Concentration: 1.25, 2.5, 5.0, 10, 20 , and 40 μM Incubation Time: 48 hours Result: Had no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM).

IC50& Target:IC50: 508 nM (LYP, in T cells)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

LTV-1 is a potent lymphoid tyrosine phosphatase ( LYP ) inhibitor in T cells with an IC 50 of 508 nM. LTV-1 has the potential for autoimmunity treatment.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=CC=CC=C1N2C(=O)/C(=C/C3=CC=C(C=C3)OCC4=CC(=CC=C4)C(=O)O)/C(=O)NC2=S
• PubChem CID: 1920999
• Molecular Weight: 472.51