LUF5771 is a potent allosteric recombinant luteinizing hormone ( recLH ) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy
In Vitro
LUF5771 (1 µM or 10 µM) allosteric inhibition is concentration-dependent. LUF5771 significantly increases radioligand dissociation. LUF5771 probably binds to the seven transmembrane domain like Org 43553 does. LUF5771 (10 µM) alone is able to partially activate the LH receptor by 31±4%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:recLH and Org 43553
仕様
仕様と純度
10mM in DMSO
生化学的・生理学的メカニズム
LUF5771 is a potent allosteric recombinant luteinizing hormone ( recLH ) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy.
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Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.
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