Manitimus - 10mM in DMSO , CAS No.202057-76-9

CAS: 202057-76-9 Cat. No.: M654653 分子式: C₁₅H₁₁F₃N₂O₂ 分子量: 308.26 PubChem CID: 54686843

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive agent.

In Vivo

In the Manitimus-treated rats, there is a dose-related, differential effect: mean survival is 15.7 days in group 4 (Manitimus 5 mg/kg), 19.1 days in group 5 (Manitimus 10 mg/kg) and 25.4 days in group 6 (Manitimus 20 mg/kg) . Manitimus (15 mg/kg, p.o.) results in a significant decrease in neointimal area and percentage of stenosis versus the control rats, and diminishes the effect that CMV infection results in a significant increase in intimal and medial cross-sectional area and medial wall thickness of the vein grafts. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal administration

The whole experiment consists of a total of four experimental groups (n = 10 animals/group) which all undergo surgery. Furthermore, rats are either infected with CMV, treated with Manitimus\nor both. A control group only receive the Manitimus solvent (1 mL of a 1% carboxymethylcellulose solution in water). Infection is established by inoculating rats intraperitoneally with 1.25×10 6 plaque-forming units of homogenized salivary gland-derived rat CMV immediately after surgery. aladdin has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive agent.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

• 異性体SMILES: C#CCC/C(=C(\C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F)/O
• 代替CAS番号: 202057-76-9,185915-33-7
• PubChem CID: 54686843
• MeSH用語: 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide;2-cyano-3-hydroxy-N-(4--(trifluoromethyl)phenyl)-2-hepten-6-ynoic acid;FK 778;FK-778;FK778;HMR 1715;HMR-1715;malononitrilamide 715;malononitrilamide-715;MNA 715;MNA-715;MNA-X 920715;X 9207
• 分子量: 308.26

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 202057-76-9, the molecular formula is C15H11F3N2O2, and the molecular weight is 308.26 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.