Maprotiline HCl - ≥99%(HPLC) , Norepinephrine transporter inhibitor, CAS No.10347-81-6, Norepinephrine transporter inhibitor

CAS: 10347-81-6 Cat. No.: M129850 分子式: C₂₀H₂₃N·HCl 分子量: 313.86 EC番号: 233-758-8

GRADE & PURITY ≥99%(HPLC)

Synonyms

Maprotiline HCl;Ludiomil;Psymion | MAPROTILINE HYDROCHLORIDE [WHO-DD] | AC-8249 | Deoxycortone | DPPC (phosphatide) | KS-5095 | Q27268058 | REGID_for_CID_71478 | Thonzylamine (hydrochloride) | (L)-Phenylalanine | NSC 757085 | SR-01000076016-1 | cytidylate

Storage

Room temperature

Shipped In

Normal

概要

A norepinephrine reuptake inhibitor shown to block apoptosis of spiny neurons.

Specifications

同義語

Maprotiline HCl;Ludiomil;Psymion | MAPROTILINE HYDROCHLORIDE [WHO-DD] | AC-8249 | Deoxycortone | DPPC (phosphatide) | KS-5095 | Q27268058 | REGID_for_CID_71478 | Thonzylamine (hydrochloride) | (L)-Phenylalanine | NSC 757085 | SR-01000076016-1 | cytidylate

仕様と純度

≥99%(HPLC)

生化学的・生理学的メカニズム

Maprotiline HCl is an inhibitor of norepinephrine reuptake. It acts primarily by potentiation of central adrenergic (AR) synapses by blocking reuptake of norepinephrine at nerve endings. Maprotiline Hydrochloride has also been shown to block apoptosis of

保管条件

Room temperature

入荷

Normal

アクションタイプ

INHIBITOR

作用メカニズム

Norepinephrine transporter inhibitor

注

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

純度

≥99%(HPLC)

名前と識別子

• パブケム・シド: 504754627
• パブケム・シド・ウル: https://pubchem.ncbi.nlm.nih.gov/substance/504754627
• カノニカル・スマイル: CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl
• IUPAC Name: N-methyl-3-(1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl)propan-1-amine;hydrochloride
• InChIKey: NZDMFGKECODQRY-UHFFFAOYSA-N
• INCHI: 1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H
• 異性体SMILES: CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl
• WGKドイツ: 3
• RTECS: KJ4555000
• 分子量: 313.86
• Reaxy-Rn: 5463242
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5463242&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Anthracenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Anthracenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Anthracenes
• Alternative Parents: Tetralins Aralkylamines Dialkylamines Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Anthracene - Tetralin - Aralkylamine - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Amine - Aromatic homopolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as anthracenes. These are organic compounds containing a system of three linearly fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

HRH1 Tclin Histamine H1 receptor (0 Activities)

Discover Target: HRH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A2 Tclin Sodium-dependent noradrenaline transporter (0 Activities)

Discover Target: SLC6A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (0 Activities)

Discover Target: CHRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 (0 Activities)

Discover Target: CHRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A (0 Activities)

Discover Target: HTR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2C Tclin 5-hydroxytryptamine receptor 2C (0 Activities)

Discover Target: HTR2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: DMSO 63 mg/mL Water Ethanol 24 mg/mL
• 感度: Light & Heat Sensitive.
• 融点（°C）: 242 °C
• 分子量: 313.900 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 313.16 Da
• Monoisotopic Mass: 313.16 Da
• Topological Polar Surface Area: 12.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 339.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3