MASM7 - Moligand™,≥97% , CAS No.920868-45-7

CAS: 920868-45-7 Cat. No.: M648254 分子式: C₂₂H₂₃N₅O₂S₂ 分子量: 453.58 EC番号: 844-446-1 PubChem CID: 16347380

GRADE & PURITY Moligand™, ≥97%

Synonyms

2-(2-((5-Cyclopropyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)propanamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

概要

MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC 50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with K d value of 1.1 μM.

In Vitro

MASM7 (1-10 μM, 2 h) increases Mito AR with an EC 50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 (1-1000 μM, 5 min) demonstrates direct binding to the HR2 domain of MFN2 with K d value of 1.1 μM. MASM7 (1 μM, 6 h) does not induce DNA damage in any of the cell lines. MASM7 (0-1.5 μM, 72 h) does not decrease cellular viability over the course of 72 h. MASM7 (1 μΜ, 6 h) does not induce caspase-3/7 activation in U2OS cells. MASM7 (0-1 μM, 6 h) increases mitochondrial membrane potential in WT MEFs.

Form:Solid

Specifications

同義語

2-(2-((5-Cyclopropyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)propanamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

仕様と純度

Moligand™,≥97%

生化学的・生理学的メカニズム

MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC 50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MA

保管条件

Store at 2-8°C,Argon charged

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

純度

≥97%

名前と識別子

• 異性体SMILES: CC(C(=O)NC1=C(C2=C(S1)CCC2)C(=O)N)SC3=NN=C(N3C4=CC=CC=C4)C5CC5
• PubChem CID: 16347380
• 分子量: 453.58

化学的性質と物理的性質

• 溶解度: DMSO : 125 mg/mL (275.59 mM; ultrasonic and warming and heat to 60°C)
• 分子量: 453.600 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 453.129 Da
• Monoisotopic Mass: 453.129 Da
• Topological Polar Surface Area: 156.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 687.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

よくある質問

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 920868-45-7, the molecular formula is C22H23N5O2S2, and the molecular weight is 453.58 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.