MB 0223 - ≥98%以上(HPLC) , CAS No.2247732-89-2

CAS: 2247732-89-2 Cat. No.: M288737 分子式: C₂₆H₂₇N₅OS 分子量: 457.59

グレード＆純度 ≥98%(HPLC)

Synonyms

4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide

Storage

20℃で保存

Shipped In

アイスチェスト＋アイスパッド

仕様

同義語

4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide

仕様と純度

≥98%以上(HPLC)

生化学的・生理学的メカニズム

ダイナミン関連GTPase DRP1部分阻害剤（IC50= 1.2 μM）。他のダイナミン関連GTPase、OPA1、DYN1よりもDRP1に選択的。ミトコンドリア融合不全のmfn1ノックアウトMEFにおいてミトコンドリアDNA量を増加させる。

保管条件

20℃で保存

入荷

アイスチェスト＋アイスパッド

アクションタイプ

INHIBITOR

純度

≥98%(HPLC)

名前と識別子

カノニカル・スマイル

CC1=CN(C(=C1)C(=O)NC2=CC=C(C=C2)C3=CN=CC=C3)CC4=CSC(=N4)N5CCCCC5

IUPAC Name

4-methyl-1-[(2-piperidin-1-yl-1,3-thiazol-4-yl)methyl]-N-(4-pyridin-3-ylphenyl)pyrrole-2-carboxamide

InChIKey

SWLKFZCOJAYAMJ-UHFFFAOYSA-N

INCHI

1S/C26H27N5OS/c1-19-14-24(25(32)28-22-9-7-20(8-10-22)21-6-5-11-27-15-21)31(16-19)17-23-18-33-26(29-23)30-12-3-2-4-13-30/h5-11,14-16,18H,2-4,12-13,17H2,1H3,(H,28,32)

異性体SMILES

CC1=CN(C(=C1)C(=O)NC2=CC=C(C=C2)C3=CN=CC=C3)CC4=CSC(=N4)N5CCCCC5

分子量

457.59

Reaxy-Rn

32649234

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32649234&ln=

作用メカニズム

化学的性質と物理的性質

• 溶解度: Solvent:DMSO, Max Conc. mg/mL: 45.76, Max Conc. mM: 100

よくある質問

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2247732-89-2, the molecular formula is C??H??N?OS, and the molecular weight is 457.59 g/mol. InChIKey SWLKFZCOJAYAMJ-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.