MCC Pellet

Cat. No.: M1373792

Storage

Room temperature,Desiccated

Shipped In

Normal

概要

This product is a white or quasi white spherical pellet made of microcrystalline cellulose. The
Purpose
Pharmaceutical excipients are mainly used as carriers of enteric coated pellets and sustained-release pellets. The
Product features
1. Low adhesion between particles: prevent particle adhesion in the process of drug application, improve coating efficiency and reduce coating cost.
2. Extremely low brittleness: it hardly breaks in the normal coating process, and the brittleness is the lowest among all pill cores.
3. Do not dissolve in water: do not produce osmotic pressure, do not affect the release rate of drugs in the coating layer, can also be used in traditional Chinese medicine preparations, and can absorb traditional Chinese medicine flow extract.
4. Sugar free: suitable for diabetes drugs, etc.
5. Wide application range: small size (0.15-0.212mm, 70-100 mesh) is suitable for suspensions, dispersible tablets, etc.
6. Good physical and chemical stability: it does not affect the content of drugs and does not produce compatible reaction with drugs, but MCC will degrade the content of prazole drugs.

SKU	Specifications
M1373792-01	300-500μm
M1373792-02	400-600μm
M1373792-03	500-700μm
M1373792-04	600-800μm
M1373792-05	700-900μm
M1373792-06	710-850μm
M1373792-07	800-1000μm
M1373792-08	1000-1180μm

仕様

保管条件

Room temperature,Desiccated

入荷

Normal

化学的性質と物理的性質

• 感度: Moisture sensitive

Application Protocols

General laboratory protocols for MCC pellets (guidance only; optimize for your setup):

• Conditioning and moisture equilibration
  • Dry or equilibrate pellets to a defined relative humidity (e.g., 30–50% RH) for 24–48 h to stabilize plasticity and flow before processing.
• Coating in a fluid-bed or pan coater
  • Preheat/dry pellets to remove surface moisture.
  • Spray aqueous or hydroalcoholic coating solution at controlled inlet temperature and atomization pressure to avoid overwetting; use intermittent drying if necessary.
  • Target weight gain by in-process mass balance; assess film formation by disintegration/dissolution tests.
• Extrusion–spheronization (if using pellets as seeds or products)
  • Prepare a wet mass with MCC, binder, and controlled water content; extrude through appropriate die; spheronize to target size; dry at 40–60 °C.
  • For layering actives, use the pellets as neutral cores and apply binder/active solutions with staged drying.
• Functionalization (surface modification)
  • Conduct heterogeneous reactions under conditions that maintain pellet integrity; limit exposure times and temperatures; rinse thoroughly and redry.
• Quality checks
  • Particle size distribution (sieving or laser diffraction), friability, bulk/tapped density, moisture (LOD/Karl Fischer), and visual sphericity (microscopy/SEM).

Note: Specific operating parameters (temperatures, flow rates, binder ratios) are process- and equipment-dependent and are not specified for this item.

Biological Roles

Contextual information on cellulose (general, literature-based):

• Natural function
  • Cellulose is the primary structural polysaccharide in plant cell walls, forming microfibrils that provide tensile strength and scaffold for hemicellulose/pectin matrices.
  • The β(1→4)-D-glucan chains aggregate via hydrogen bonding, yielding crystalline domains (Iα/Iβ) interspersed with amorphous regions.
• Biodegradation and metabolism
  • Many microorganisms and some animals (via symbiotic microbes) produce cellulases that hydrolyze β(1→4) linkages to glucose/oligosaccharides.
  • Humans lack endogenous cellulases; cellulose is not digested, functioning as insoluble dietary fiber in food contexts (note: this product is for research use only and not intended for consumption).
• Interaction with biomolecules
  • Hydroxylated surfaces adsorb proteins/polysaccharides through hydrogen bonding and hydrophobic interactions at crystalline faces; surface-modified cellulose can present ligands for biospecific binding.
• Biomedical materials perspective
  • Cellulose and its derivatives are widely studied for scaffolds, films, and carrier systems due to biocompatibility and low cytotoxicity in vitro. MCC pellets can act as inert carriers for laboratory dosing, release studies, or coating-method development.
• Note
  • The above reflects general literature knowledge; no biological properties are specified or claimed for this specific item.

Buffer Applications

Not typically applicable. MCC pellets are solid cellulosic carriers and do not function as pH buffers. If using MCC in buffered systems (e.g., coating in phosphate or acetate buffers), ensure buffer selection is compatible with your active/polymer and does not over-wet or erode pellet integrity. Refer instead to the “Reaction & Applications” and “Application Protocols” tabs for processing guidance.

Green Alternatives

MCC is itself a bio-based, renewable material with favorable green credentials compared to many petroleum-derived carriers and polymeric excipients.

• Sustainability perspective (general)
  • Feedstock: Derived from wood pulp or plant biomass; high biogenic carbon content.
  • Processing: Acid hydrolysis and purification yield MCC; impacts depend on energy/water use and effluent treatment.
  • End-of-life: Biodegradable under appropriate conditions; combusts cleanly to CO2 and water.
• Comparisons and trade-offs

| Carrier/support | Source | Solubility/processing | Environmental notes | |---|---|---|---| | MCC Pellets | Renewable cellulose | Insoluble; water-based processing; coatability | Biodegradable; low toxicity; dust management needed | | Polystyrene beads | Petrochemical | Solvent-processed; good sphericity | Non-biodegradable; microplastic concerns | | Silica spheres | Mineral/inorganic | Robust; solvent/thermal tolerance | Non-renewable; dust is respirable (silicosis risk) | | Lactose pellets | Biobased disaccharide | Water soluble; hygroscopic | Biodegradable; solubility can limit release profiles |

• Greener processing suggestions
  • Favor aqueous or hydroalcoholic coatings over chlorinated or high-VOC solvents.
  • Use waterborne binders and low-temperature drying with heat recovery.
  • Select ionic liquids or DMAc/LiCl only when necessary for derivatization; recover and recycle solvents where possible.
  • Implement dust capture and energy-efficient spheronization/drying to reduce emissions.

Pharmaceutical Uses

For research and development context only (no clinical claims):

• Role as excipient (general literature)
  • Microcrystalline cellulose is a benchmark excipient for direct compression, wet granulation, and extrusion–spheronization due to its plastic deformation, wicking, and binding capacity.
  • Pellet forms serve as neutral cores for drug layering, taste-masking, and controlled-release coatings, providing uniform sphericity and flow.
• Functional properties relevant to formulation
  • Compressibility: Facilitates robust tablets at moderate compaction pressures; balances hardness with disintegration when combined with superdisintegrants.
  • Capillarity: Promotes rapid uptake of granulation fluid and uniform distribution, critical in spheronization.
  • Coating substrate: Smooth, low friability pellets enable reproducible film formation and narrow dissolution profiles.
• Selection considerations
  • Pellet size distribution, porosity, and surface roughness govern coating weight gain, bed fluidization behavior, and content uniformity.
  • Moisture content influences plasticity and friability; equilibrate materials to a controlled RH prior to processing.
• Regulatory context
  • Many MCC grades meet pharmacopeial monographs (e.g., USP/NF, Ph. Eur.) at the grade level; however, for this item, no pharmacopeial status is specified. Users should consult the CoA/Spec Sheet and qualify the material for intended R&D uses.

Physical Properties

• Item-specific properties
  • Appearance: Not specified for this item; refer to CoA/Spec Sheet. (Product name indicates pellet form.)
  • Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.
• Literature/general properties of microcrystalline cellulose (MCC)
  • Physical state: Odorless, tasteless solid; typically white to off-white.
  • Melting/decomposition: No sharp melting; thermally decomposes rather than melts. Onset of thermal degradation often reported around 260–300 °C in inert atmosphere (literature), with moisture loss below 120 °C.
  • Density: True density ~1.5–1.6 g/cm3 (literature). Bulk density varies widely with grade and pellet size/porosity (commonly ~0.2–0.5 g/cm3; literature ranges).
  • Solubility: Insoluble in water and common organic solvents; swells in water; dispersible under shear. Soluble in specialized solvent systems (e.g., DMAc/LiCl, N-methylmorpholine N-oxide, certain ionic liquids) for derivatization (literature).
  • Hygroscopicity: Moderately hygroscopic; equilibrates to ambient humidity (adsorbed water typically 3–7% at 50% RH; literature), influencing flow and compressibility.
  • Particle attributes: MCC pellets are generally spherical/near-spherical agglomerates with internal porosity; specific surface area and median diameter depend on manufacturing (not specified for this item).
  • pH (slurry): Aqueous slurry of MCC is typically neutral to slightly acidic (literature), but exact value depends on grade and wash history.
  • Optical: White, high light-scatter from microstructure; refractive index around 1.47–1.55 (literature for cellulose).

Quality and Grades

• Item-specific grade
  • Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.
• Context on MCC grades (general information)
  • MCC materials are commonly differentiated by particle size distribution (PSD), degree of polymerization (DP), crystallinity, moisture content, and flow/compressibility indices (e.g., Hausner ratio, Carr index). Pellet grades are typically spheronized to defined diameters with narrow PSD to enable uniform coating and predictable flow.
  • Excipient-oriented grades may be tested for loss on drying, pH (slurry), ash, heavy metals, endotoxins/bioburden (where applicable), and specific surface area. Materials science grades may emphasize mechanical strength, porosity, and surface chemistry.
  • UV/background absorbance: MCC is non-UV-absorbing above deep UV; however, extractables can contribute to background—low extractables grades are sometimes specified for analytical uses.
• Stabilizers/additives
  • Typical MCC contains no intentional organic stabilizer; small amounts of bound water are normal. Any processing aids (e.g., trace binders during pelletization) should be disclosed on the CoA if present. For this item, such details are not specified; refer to CoA/Spec Sheet.
• Selecting a grade
  • For tableting/spheronization: choose pellet size, friability, and porosity to match coating processes.
  • For composite reinforcement: prioritize low moisture, defined PSD, and high crystallinity for improved modulus and dispersion.

Reaction and Applications

MCC Pellets function primarily as a structured cellulosic carrier and material rather than as a small-molecule reagent. Applications focus on formulation, coating, and materials engineering; reactions are generally surface or bulk modifications.

• Materials/formulation applications (general)
  • Pellet cores for layering actives, functional coatings, and controlled-release architectures; the spherical geometry supports uniform film deposition and predictable flow.
  • Extrusion–spheronization seed or product: MCC’s plasticity with water/binders enables robust pellets after drying.
  • Porous support/adsorbent: Hydroxyl-rich surface interacts via hydrogen bonding; can be derivatized to tune hydrophilicity or introduce functional groups.
  • Composite reinforcement: Enhances stiffness in biocomposites; good compatibility with biodegradable matrices (PLA, PHB) when surface-treated.
• Chemical modification (literature examples)
  • Esterification: Formation of cellulose acetate/propionate/butyrate on surface or bulk using acylating agents; control of degree of substitution tunes hydrophobicity.
  • Etherification: Carboxymethylation, hydroxypropylation for improved water dispersibility or binding.
  • Grafting: Surface-initiated radical polymerization (e.g., ATRP) to graft synthetic polymers for tailored interfaces.
• Practical tips
  • Control moisture: 3–6% water facilitates plastic deformation during pellet processes; for coatings, equilibrate to target RH for reproducible uptake.
  • Avoid over-wetting: Maintain integrity by using atomized spray and intermediate drying steps.
  • For reactions, consider heterogeneous protocols to preserve pellet morphology; monitor via SEM/FTIR and mass gain.

Reaction Conditions

General literature guidance for modifying cellulose/MCC pellets; adjust to preserve pellet integrity and verify with pilot trials:

• Esterification (surface/bulk)
  • Reagents: Acyl chlorides or anhydrides (e.g., acetyl chloride, acetic anhydride) with base catalysts (pyridine, DMAP) or acid catalysts.
  • Solvent systems: Heterogeneous in aprotic solvents with minimal swelling (toluene, acetone) for surface modification; homogeneous in DMAc/LiCl or ionic liquids for higher substitution.
  • Conditions: 0–80 °C for surface treatments; 60–120 °C for homogeneous systems. Reaction time from 0.5–24 h depending on target substitution (literature ranges).
• Etherification
  • Reagents: Epoxides (propylene oxide, epichlorohydrin), haloacetates, monochloroacetic acid (for carboxymethylation) with alkaline activation (NaOH) under controlled moisture.
  • Media: Isopropanol/water or ethanol/water for heterogeneous processes; ionic liquids for homogeneous.
• Grafting polymerizations
  • ATRP/RAFT from surface-anchored initiators; typical catalysts (CuBr/ligand for ATRP). Temperatures 25–90 °C depending on monomer.
• Metal nanoparticle loading
  • Adsorb metal salts (e.g., HAuCl4, Pd(OAc)2) from aqueous/alcoholic media; reduce with NaBH4 or ascorbate at 0–25 °C; wash and dry.
• Drying and post-treatment
  • Dry at 40–60 °C under vacuum or dehumidified air to restore mechanical strength; avoid collapse by limiting prolonged solvent immersion.
• Yields and characterization
  • Reported degrees of substitution range 0.1–2.5 (literature), with mass gains correlating. Characterize by FTIR (C=O at ~1735 cm−1 for esters), elemental analysis, and TGA.

Note: These are literature-derived ranges and not specifications for this item.

Safety and Handling

• GHS classification and hazard statements
  • Signal Word: Not specified for this item; refer to SDS.
  • H-Statements: Not specified for this item; refer to SDS.
  • GHS Classification: Not specified for this item; refer to SDS.
  • Pictograms: Not specified for this item; refer to SDS.
• General safety notes for MCC (literature/practice)
  • Inhalation of dust may cause mechanical irritation; nuisance dust limits apply. Manage as a potential combustible dust—fine cellulose dust can form explosive mixtures with air under strong dispersion/ignition.
  • Skin/eye contact: Generally low hazard; fine particles can cause dryness or irritation. Wash with water; seek medical attention if irritation persists.
  • Ingestion: Low acute toxicity; intended strictly for research/lab use only.
• Storage and incompatibilities
  • Storage conditions (product data): Room temperature, desiccated. Keep container tightly closed to control moisture uptake and maintain flow/compressibility. Shipped at ambient conditions.
  • Incompatibilities: Strong oxidizers (e.g., nitric acid, peroxides), strong acids/bases at elevated temperature (can hydrolyze/oxidize). Avoid ignition sources and dust clouds.
• Handling and PPE
  • Use in well-ventilated area or under local exhaust, especially during pouring/sieving to control dust.
  • Recommended PPE: Safety glasses, lab coat, suitable gloves; dust mask/respirator (e.g., P2/P95) if dust generation cannot be controlled.
• Spill/cleanup
  • Avoid dry sweeping if dust is airborne; use HEPA vacuum or damp methods. Dispose of in accordance with local regulations.
• Fire response
  • Class A combustible solid; extinguish with water spray, foam, or dry chemical. Smoldering can persist—monitor for re-ignition.

Solvent Selection

This product is a solid polymeric material (MCC pellets), not a solvent. Traditional solvent-selection frameworks do not directly apply. However, solvent interactions matter in processing and functionalization.

• Swelling/dispersion behavior (literature/general)
  • Water: Insoluble; swells and disperses under shear. Water content strongly affects flow and compressibility.
  • Alcohols (MeOH, EtOH, IPA): Insoluble; limited swelling; used as wetting agents or granulation fluids.
  • Polar aprotic solvents: Generally insoluble; DMAc/LiCl systems disrupt hydrogen bonding and can dissolve cellulose for derivatization.
  • Ionic liquids (e.g., EMIMAc, BMIMCl): Dissolve cellulose under heat for homogeneous modification; regeneration precipitates MCC-like solids.
• Practical selection for processing
  • For coating pellets: Choose solvents compatible with actives/polymers while avoiding over-wetting that collapses porosity. Aqueous or hydroalcoholic systems are common.
  • For composite compounding: Use compatibilizers or surface treatments rather than relying on solvent dissolution; dry blending with thermoplastics under controlled moisture can improve dispersion.
• Alternatives
  • If dissolution is required for chemical modification, consider direct dissolution in suitable ionic liquids or DMAc/LiCl; otherwise use heterogeneous surface reactions in water/alcohol to preserve pellet integrity.

Storage and Reconstitution

• Storage (product data)
  • Store at room temperature, desiccated. Keep container tightly closed to limit moisture uptake and preserve flow and mechanical properties.
  • Shipped: Normal ambient conditions.
• Handling after opening
  • Minimize exposure to high humidity; consider using desiccant packs in the container. Record opening date and track moisture via LOD if critical to process.
• Reconstitution/Preparation for use
  • Pellets are supplied ready-to-use; no reconstitution is generally required.
  • For coating or wet processing, precondition moisture content (e.g., equilibrate at a target RH) and, if needed, pre-warm/dry to remove surface moisture.
  • For slurry preparation, disperse under moderate shear in water or hydroalcoholic media; avoid excessive agitation that could fracture pellets if integrity must be preserved.
• Stability considerations
  • Avoid strong oxidizers and extreme heat. Prolonged exposure to UV/ozone can induce surface oxidation.
  • Under recommended conditions, MCC is physically stable; periodic checks of moisture content and friability are advisable for long-term stored lots.
• Disposal
  • Dispose of as non-hazardous laboratory solid waste unless contaminated. Follow local regulations.

Structure and Identity

Brief overview: MCC (microcrystalline cellulose) is a partially depolymerized, crystalline fraction of cellulose, supplied here as pelletized particles for materials applications.

• Item-specific identifiers
  • CAS: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet. (Note: cellulose is a polymer; see literature for repeating unit.)
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet. (Polymeric distribution.)
  • SMILES: Not specified for this item; polymers do not have a single canonical SMILES.
  • InChIKey: Not applicable for a polymer distribution.
• Literature/general structural information (for context)
  • Polymer type: β(1→4)-linked D-glucopyranose polysaccharide; MCC is enriched in crystalline regions (Iα/Iβ allomorphs).
  • Repeating unit: anhydro-D-glucose, formula (C6H10O5)n; repeat MW ≈ 162.14 g/mol (literature).
  • Stereochemistry: Each glucose is in the 4C1 chair; β-glycosidic linkages define linear chains with extensive intra/inter-chain hydrogen bonding.
  • Supramolecular structure: Elementary fibrils aggregate into microfibrils; MCC preparation increases crystallinity and shortens chain length, yielding brittle, free-flowing particles.
• 2D/functional group description
  • Functional groups: Multiple secondary alcohols and one primary alcohol per repeating unit; acetal linkage at C1–O–C4 between monomers.
  • Key features: Polyhydroxylated backbone enabling hydrogen bonding, surface hydroxyls available for chemical derivatization (esterification, etherification) or adsorption.
• Physical form
  • Supplied form: Pellet (spheronized/compacted cellulose particles; exact dimensions/PSD not specified for this item).

Synthetic Utility

While MCC pellets are not classical reagents, cellulose’s surface hydroxyl chemistry and porous, high-area morphology enable several synthetic and preparative utilities (general literature):

• Solid support and catalyst carrier
  • Immobilization of catalysts/ligands via covalent ether/ester linkages or adsorption, enabling heterogeneous catalysis in flow or batch while leveraging pellet flowability.
  • Metal nanoparticle supports (e.g., Au, Pd) prepared by adsorption/reduction on cellulose, facilitating green catalytic protocols in water or alcohol.
• Derivatization platform
  • Surface-selective esterifications (acyl chlorides/anhydrides) and etherifications (epoxides, haloalkanes) modify hydrophobicity and adhesion, preserving pellet geometry.
  • Grafting-from polymerizations (ATRP, RAFT) using initiators introduced onto cellulose hydroxyls create tailored interphases for composite bonding.
• Separation and adsorption
  • Functionalized pellets act as scavengers for acids, bases, or metals, or as matrix for ion-exchange/affinity separations.
• Retrosynthetic value
  • When a spherical, renewable, and modifiable support is required, MCC pellets can replace polystyrene or silica beads, avoiding halogenated solvents and fragile silica handling.
• Practical notes
  • Reaction access is diffusion-limited; optimize solvent wetting and consider pre-swelling in compatible media.
  • Monitor degree of substitution to avoid embrittlement or loss of mechanical integrity; characterize by FTIR, solid-state NMR, TGA, and mechanical friability tests.

Target Specificity

Not applicable. This product is a cellulosic material (MCC pellets), not a biological macromolecule or analytical antibody. No target, epitope, or species reactivity applies.

よくある質問

How should this product be stored?

Store at room temperature, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships under standard ambient conditions. No temperature-controlled packaging is required.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.