10mM in DMSO ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。
Store at -80°C Dry ice packs + Cold packs に出荷。正確な仕様については、ロット固有の COA をご確認ください。
SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。
クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。
Information
ME-401 (PWT-143, P110δ-IN-1) is an oral, potent and selective inhibitor ofPhosphatidylinositol 3-Kinase (PI3K) P110δwith IC50 of 0.6 nM in cellular assay.
Targets
P110δ (Cell-free assay) 0.6 nM
In vivo
ME-401 is an oral, once-daily, selective PI3Kδ inhibitor with an optimized pharmacologic profile that is in clinical development for the treatment of B-cell malignancies. ME-401 can be orally absorbed, distribute to target tissues, enter and accumulate in target cells, and bind to the target with high affinity to exert its mechanism of action.
危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。
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| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| 分類 | Piperidines |
| Subclass | Phenylpiperidines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylpiperidines |
| Alternative Parents | Sulfinylbenzimidazoles Amphetamines and derivatives Phenylpropanes 1,3,5-triazine-2,4-diamines Dialkylarylamines Aralkylamines 1,3,5-triazines N-substituted imidazoles Morpholines Sulfones Heteroaromatic compounds Trialkylamines Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phenylpiperidine - Sulfinylbenzimidazole - Amphetamine or derivatives - Benzimidazole - Phenylpropane - 2,4-diamine-s-triazine - Dialkylarylamine - Aminotriazine - Aralkylamine - Amino-1,3,5-triazine - Morpholine - N-substituted imidazole - Monocyclic benzene moiety - Oxazinane - Triazine - Benzenoid - 1,3,5-triazine - Heteroaromatic compound - Imidazole - Sulfone - Sulfonyl - Azole - Tertiary amine - Tertiary aliphatic amine - Oxacycle - Azacycle - Dialkyl ether - Ether - Hydrocarbon derivative - Organonitrogen compound - Amine - Organooxygen compound - Organosulfur compound - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group. |
| External Descriptors | Not available |
| DMSO（mg / mL） 最大溶解度 | 20 |
|---|---|
| DMSO（mM） 最大溶解度 | 33.0704234667725 |
| 水（mg / mL） 最大溶解度 | ＜1 |
| 分子量 | 604.800 g/mol |
| XLogP3 | 4.600 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 8 |
| Exact Mass | 604.294 Da |
| Monoisotopic Mass | 604.294 Da |
| Topological Polar Surface Area | 127.000 Ų |
| Heavy Atom Count | 43 |
| Formal Charge | 0 |
| Complexity | 1010.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
