Mepazine(Cas No 60-89-9) Moligand™, ≥98% high purity and research grade

Name: Mepazine - Moligand™, ≥98% , Mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibitor, CAS No.60-89-9, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibitor
Brand: Aladdin Scientific
SKU: M668738
Availability: InStock

Mepazine - Moligand™, ≥98% , Mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibitor, CAS No.60-89-9, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibitor

CAS: 60-89-9 Cat. No.: M668738 分子式: C₁₉H₂₂N₂S 分子量: 310.46

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Mepazine - Moligand™, ≥98% CAS No(60-89-9) by Aladdin Scientific

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注文可能

グレード＆純度 Moligand™ ? ≥98%

Synonyms

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要仕様名前と識別子ドキュメント詳細データ Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質ソリューション計算機レビューよくある質問

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このグレードを選ぶ理由

Moligand™, ≥98% Moligand™ ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。

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保管・配送

Store at -20°C Ice chest + Ice pads に出荷。正確な仕様については、ロット固有の COA をご確認ください。

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品質書類

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文献的裏付け

クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。

概要

Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC 50 s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis

In Vitro
Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) Concentration: 5, 10, and 20 μM Incubation Time: 4 days Result: Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.

In Vivo
Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rg (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6- to 8-week-old female NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model Dosage: 400 μg per animal (25 g), corresponding to approximately 16 mg/kg. Administration: Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result: Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.

仕様

同義語

仕様と純度

Moligand™, ≥98%

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibitor

純度

≥98%

名前と識別子

カノニカル・スマイル

CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42

IUPAC Name

10-[(1-methylpiperidin-3-yl)methyl]phenothiazine

InChIKey

CBHCDHNUZWWAPP-UHFFFAOYSA-N

INCHI

1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3

異性体SMILES

CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42

代替CAS番号

24360-97-2；2975-36-2

分子量

310.46

ドキュメント

📋 安全データシート（SDS）

危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。

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✅ 分析証明書（COA）

ロット固有の品質データ。ロット番号を入力して、正確な COA を取得してください。

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📊 データシート

製品仕様と用途のクイックリファレンス概要。

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🔬 仕様書

このグレードの完全な品質特性と合格基準。

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詳細データ

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 分類 Benzothiazines
    - Subclass Phenothiazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
分類	Benzothiazines
Subclass	Phenothiazines
Intermediate Tree Nodes	Not available
Direct Parent	Phenothiazines
Alternative Parents	Alkyldiarylamines Diarylthioethers Piperidines Benzenoids 1,4-thiazines Trialkylamines Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenothiazine - Alkyldiarylamine - Diarylthioether - Aryl thioether - Tertiary aliphatic/aromatic amine - Para-thiazine - Piperidine - Benzenoid - Tertiary amine - Tertiary aliphatic amine - Azacycle - Thioether - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
説明	This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

Lot Number	Certificate Type	日付	商品
J2530786	Certificate of Analysis	Oct 21, 2025	M668738
J2530787	Certificate of Analysis	Oct 21, 2025	M668738
J2530788	Certificate of Analysis	Oct 21, 2025	M668738
J2530792	Certificate of Analysis	Oct 21, 2025	M668738
J2530793	Certificate of Analysis	Oct 21, 2025	M668738
J2530794	Certificate of Analysis	Oct 21, 2025	M668738

分子量	370.500 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	370.171 Da
Monoisotopic Mass	370.171 Da
Topological Polar Surface Area	69.100 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	383.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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レビュー

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 60-89-9, the molecular formula is C19H22N2S, and the molecular weight is 310.46 g/mol. InChIKey CBHCDHNUZWWAPP-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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