Methacycline HCl - 10mM in Water , CAS No.3963-95-9

CAS: 3963-95-9 Cat. No.: M407975 分子式: C₂₂H₂₂N₂O₈·HCl 分子量: 478.88 Beilstein Registry Number: 5470951 EC番号: 223-568-3

GRADE & PURITY 10mM in Water

Synonyms

Rondomycin | (4S,​4aR,​5S,​5aR,​12aS)​- 4-​(dimethylamino)​-​1,​4,​4a,​5,​5a,​6,​11,​12a-​octahydro-​3,​5,​10,​12,​12a-​pentahydroxy-​6-​methylene-​1,​11-​dioxo-​2-​naphthacenecarboxami​de, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Methacycline HCl Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.
In vitro

Methacycline\xa0inhibits TGF-β1-induced α-smooth muscle actin, Snail1, and collagen I of primary alveolar epithelial cells. Methacycline inhibits TGF-β1-induced non-Smad pathways, including c-Jun N-terminal kinase, p38, and Akt activation, but not Smad or β-catenin transcriptional activity. Methacycline has no effect on baseline c-Jun N-terminal kinase, p38, or Akt activities or lung fibroblast responses to TGF-β1.

In vivo

Methacycline\xa0(100 mg/kg, i.p.) delivered daily beginning 10 days after intratracheal bleomycin improves survival at Day 17. Methacycline attenuates Bleomycin-induced canonical EMT markers, Snail1, Twist1, collagen I, as well as fibronectin protein and mRNA. Methacycline\xa0does not attenuate inflammatory cell accumulation or alter TGF-β1-responsive genes in alveolar macrophages.\xa0
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

Rondomycin | (4S,​4aR,​5S,​5aR,​12aS)​- 4-​(dimethylamino)​-​1,​4,​4a,​5,​5a,​6,​11,​12a-​octahydro-​3,​5,​10,​12,​12a-​pentahydroxy-​6-​methylene-​1,​11-​dioxo-​2-​naphthacenecarboxami​de, hydrochloride (1:1)

仕様と純度

10mM in Water

生化学的・生理学的メカニズム

Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

異性体SMILES

CN(C)[C@H]1[C@@H]2[C@H]([C@@H]3C(=C)C4=C(C(=CC=C4)O)C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O.Cl

分子量

478.88

Beilstein

5470951

Reaxy-Rn

25461541

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25461541&ln=

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 100 mg/mL (139.12 mM); Water: Insoluble; Ethanol: Insoluble
• 融点（°C）: >190°C