MHY1485 - 10mM in DMSO , CAS No.326914-06-1

CAS: 326914-06-1 Cat. No.: M408199 分子式: C₁₇H₂₁N₇O₄ 分子量: 387.39

GRADE & PURITY 10mM in DMSO

Synonyms

4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

MHY1485 MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy .
In vitro

MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner. MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

同義語

4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

名前と識別子

異性体SMILES

C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCOCC4

分子量

387.39

Reaxy-Rn

9952068

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9952068&ln=

化学的性質と物理的性質

• 融点（°C）: 259°C