MI-2-2 - Moligand™,≥98% , CAS No.1454920-20-7

CAS: 1454920-20-7 Cat. No.: M647167 分子式: C₁₇H₂₀F₃N₅S₂ 分子量: 415.50

GRADE & PURITY Moligand™, ≥98%

Synonyms

4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

概要

MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (K d =22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.

In Vitro

MI-2-2 is capable of inhibiting both the interaction of menin with MBM1 (IC 50 = 46 nM) and with the bivalent fragment of MLL that comprises both MBM1 and MBM2 (IC 50 =520 nM). MI-2-2 exhibits very pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4;11, a human leukemia cell line harboring the MLL-AF4 translocation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

同義語

4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine

仕様と純度

Moligand™,≥98%

生化学的・生理学的メカニズム

MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (K d =22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leu

保管条件

Protected from light,Store at -20°C,Argon charged,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• 分子量: 415.50

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (240.67 mM; Need ultrasonic)
• 感度: light sensitive，Moisture sensitive