MI-3 - Moligand™, ≥98% , CAS No.1271738-59-0

CAS: 1271738-59-0 Cat. No.: M125633 分子式: C₁₈H₂₅N₅S₂ 分子量: 375.55 PubChem CID: 51001299

GRADE & PURITY Moligand™, ≥98%

Synonyms

Menin-MLL inhibitor 3 | 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

同義語

Menin-MLL inhibitor 3 | 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine

仕様と純度

Moligand™, ≥98%

生化学的・生理学的メカニズム

MI-3 is Menin-MLL inhibitor, inhibitors of the menin-MLL fusion protein interaction that specifically bind menin with nanomolar affinities.Potent menin-MLL\xa0interaction inhibitor (IC 50 of 648 nM). Inhibits the menin-MLL-AF9 interaction in HEK-293 cells

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

注

Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

純度

≥98%

名前と識別子

• パブケム・シド: 504770999
• パブケム・シド・ウル: https://pubchem.ncbi.nlm.nih.gov/substance/504770999
• 異性体SMILES: CC(C)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C
• PubChem CID: 51001299
• 分子量: 375.55

関連ターゲット（人間）

MEN1 Tchem Menin (1 Activities)

Discover Target: MEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin (447 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

関連ターゲット（非人間）

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO
• 分子量: 375.600 g/mol
• XLogP3: 3.700
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 375.155 Da
• Monoisotopic Mass: 375.155 Da
• Topological Polar Surface Area: 98.200 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 516.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1