Miclxin - ≥99% , CAS No.2494198-61-5

CAS: 2494198-61-5 Cat. No.: M647362 分子式: C₂₆H₂₇N₅O₂ 分子量: 441.52 PubChem CID: 155891739

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin , involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis , leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60 , a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex.

In Vitro

Miclxin (0-15 μM; 48 h) inhibits the growth of β-catenin-mutated HCT116 cells and isogenic HCT116 (CTNNB1 Δ45/-) cells, and induces (10 μM; 24 h) apoptosis in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 (CTNNB1 +/–) and (CTNNB1 △45/–) Concentration: 0, 5, 8, 10, 12, and 15 μM Incubation Time: 48 hours Result: Inhibited cell growth with inhibition rate of 100% at 15 μM.

Form:Solid

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin , involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis , leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targ

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• カノニカル・スマイル: COC1=CC2=C(C=C1)C(=NC(=N2)N3CCC(C3)C4=CN=CC=C4)NCC5=CC(=CC=C5)OC
• IUPAC Name: 7-methoxy-N-[(3-methoxyphenyl)methyl]-2-(3-pyridin-3-ylpyrrolidin-1-yl)quinazolin-4-amine
• InChIKey: OXSWPFXQCLRTCF-UHFFFAOYSA-N
• INCHI: 1S/C26H27N5O2/c1-32-21-7-3-5-18(13-21)15-28-25-23-9-8-22(33-2)14-24(23)29-26(30-25)31-12-10-20(17-31)19-6-4-11-27-16-19/h3-9,11,13-14,16,20H,10,12,15,17H2,1-2H3,(H,28,29,30)
• PubChem CID: 155891739
• 分子量: 441.52

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2494198-61-5, the molecular formula is C26H27N5O2, and the molecular weight is 441.52 g/mol. InChIKey OXSWPFXQCLRTCF-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.