Miconazole - Moligand™, 10mM in DMSO , Cytochrome P450 51 inhibitor, CAS No.22916-47-8, Cytochrome P450 51 inhibitor

CAS: 22916-47-8 Cat. No.: M407984 分子式: C₁₈H₁₄Cl₄N₂O 分子量: 416.14 EC番号: 245-324-5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1-​[2-​(2,​4-​dichlorophenyl)​-​2-​[(2,​4-​dichlorophenyl)​methoxy]​ethyl]​-1H-​imidazole

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Miconazole Miconazole (Monistat) is an imidazole antifungal agent.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥96%

Specifications

同義語

1-​[2-​(2,​4-​dichlorophenyl)​-​2-​[(2,​4-​dichlorophenyl)​methoxy]​ethyl]​-1H-​imidazole

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Miconazole (Monistat) is an imidazole antifungal agent.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

CHANNEL BLOCKER, INHIBITOR

作用メカニズム

Cytochrome P450 51 inhibitor

製品の性質

• ALogP: 5.3

名前と識別子

• 異性体SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
• 分子量: 416.14
• Reaxy-Rn: 965511
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=965511&ln=

関連ターゲット（人間）

CYP2D6 Tclin Cytochrome P450 2D6 (2 Activities)

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2J2 Tchem Cytochrome P450 2J2 (2 Activities)

Discover Target: CYP2J2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 (2 Activities)

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 (6 Activities)

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP51A1 Tchem Lanosterol 14-alpha demethylase (1 Activities)

Discover Target: CYP51A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 (2 Activities)

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter (2 Activities)

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBXAS1 Tchem Thromboxane-A synthase (1 Activities)

Discover Target: TBXAS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP19A1 Tclin Aromatase (1 Activities)

Discover Target: CYP19A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP17A1 Tclin Steroid 17-alpha-hydroxylase/17,20 lyase (1 Activities)

Discover Target: CYP17A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 30 mg/mL (46.11 mM); Water: Insoluble; Ethanol: Insoluble
• 融点（°C）: 83-97°C

参考文献

1. Xu Yang-ding, Guo Yu-jie, Mao He-rong, Xiong Zhi-xiang, Luo Meng-yu, Luo Rui-qi, Lu Shan, Huang Lu, Hong Yi.  (2023)  Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. in treating Trichophyton mentagrophytes.  Chinese Medicine,  18  (1): (1-20).  [PMID:37280712] [10.1186/s13020-023-00772-2]

2. Kamran Bashir, Zhimin Luo, Guoning Chen, Hua Shu, Xia Cui, Wen Li, Wang Lu, Qiang Fu.  (2019)  Development of Surface Molecularly Imprinted Polymers as Dispersive Solid Phase Extraction Coupled with HPLC Method for the Removal and Detection of Griseofulvin in Surface Water.  International Journal of Environmental Research and Public Health,  17  (1): (134).  [PMID:31878121] [10.3390/ijerph17010134]