≥98% ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。
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クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。
Information
MK-8719 MK-8719 is a selective and potent small molecule inhibitor of the O-GlcNAcase (OGA) enzyme with ki of 7.9nM for hOGA.
Targets
hOGA (Cell-free assay) 7.9nM(Ki)
In vitro
MK-8719 is a potent inhibitor of the human OGA enzyme with comparable activity against the corresponding enzymes from mouse, rat, and dog.
In vivo
oral administration of MK-8719 elevates brain and peripheral blood mononuclear cell O-GlcNAc levels in a dose-dependent manner. In addition, positron emission tomography imaging studies demonstrate robust target engagement of MK-8719 in the brains of rats and rTg4510 mice. In the rTg4510 mouse model of human tauopathy, MK-8719 significantly increases brain O-GlcNAc levels and reduces pathologic tau. The reduction in tau pathology in rTg4510 mice is accompanied by attenuation of brain atrophy, including reduction of forebrain volume loss as revealed by volumetric magnetic resonance imaging analysis.
Cell Research(from reference)
Cell lines：PC-12 cells
Concentrations：up to 1 mM
Incubation Time：24 h
危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。
<<<<<<< HEAD SDS をダウンロード → ======= SDS をダウンロード → >>>>>>> release248-p3Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| 分類 | Organooxygen compounds |
| Subclass | Carbohydrates and carbohydrate conjugates |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Monosaccharides |
| Alternative Parents | Oxanes Thiazolines Monothioacetals Secondary alcohols Isothioureas 1,2-diols Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Carboximidamides Azacyclic compounds Organofluorides Hydrocarbon derivatives Amines Alkyl fluorides |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Oxane - Monosaccharide - Meta-thiazoline - Monothioacetal - 1,2-diol - Isothiourea - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Organic nitrogen compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Hydrocarbon derivative - Amine - Alkyl halide - Alkyl fluoride - Alcohol - Aliphatic heteropolycyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as monosaccharides. These are compounds containing one carbohydrate unit not glycosidically linked to another such unit, and no set of two or more glycosidically linked carbohydrate units. Monosaccharides have the general formula CnH2nOn. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | 日付 | 商品 |
|---|---|---|---|
 I2607160 | Certificate of Analysis | Sep 18, 2026 | M414247 |
| I2603062 | Certificate of Analysis | Sep 14, 2026 | M414247 |
| G2416436 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416437 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416438 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416439 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416440 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416441 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416442 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416443 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416444 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416445 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| G2416446 | Certificate of Analysis | Mar 25, 2024 | M414247 |
| 溶解度 | Solubility (25°C) In vitro DMSO: 54 mg/mL (201.28 mM); Water: 54 mg/mL (201.28 mM); Ethanol: 54 mg/mL (201.28 mM); |
|---|
