MK6-83 - Moligand™, 10mM in DMSO , Activator of TRPML1;Activator of TRPML3, CAS No.1062271-24-2, Activator of TRPML1;Activator of TRPML3

CAS: 1062271-24-2 Cat. No.: M420493 分子式: C₁₆H₂₀N₂O₂S₂ 分子量: 336.47

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AKOS025147398 | MK683 | MK6-83 | 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide | 2-Thiophenesulfonamide, 5-methyl-N-(2-(1-piperidinyl)phenyl)- | GTPL9783 | s6947 | NCGC00402264-04 | 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thiophenesulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

同義語

AKOS025147398 | MK683 | MK6-83 | 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide | 2-Thiophenesulfonamide, 5-methyl-N-(2-(1-piperidinyl)phenyl)- | GTPL9783 | s6947 | NCGC00402264-04 | 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thiophenesulfonamide

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

TRPML channel activator (EC50= 110 nM). Also activates F408Δand F465L TRPML mutants (EC50values are 0.1 and 1.23μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.MK6-8

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ACTIVATOR

作用メカニズム

Activator of TRPML1;Activator of TRPML3

名前と識別子

パブケム・シド

528765482

カノニカル・スマイル

CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3

IUPAC Name

5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide

InChIKey

IRGYSXZCDAWOOC-UHFFFAOYSA-N

INCHI

1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3

異性体SMILES

CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3

分子量

336.47

Reaxy-Rn

41646062

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=41646062&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 分類 Piperidines
      • Subclass Phenylpiperidines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 分類: Piperidines
• Subclass: Phenylpiperidines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpiperidines
• Alternative Parents: Sulfanilides Dialkylarylamines Aniline and substituted anilines 2,5-disubstituted thiophenes Organosulfonamides Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenylpiperidine - Sulfanilide - Tertiary aliphatic/aromatic amine - Aniline or substituted anilines - Dialkylarylamine - 2,5-disubstituted thiophene - Monocyclic benzene moiety - Organosulfonic acid amide - Benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Thiophene - Aminosulfonyl compound - Heteroaromatic compound - Tertiary amine - Azacycle - Organic nitrogen compound - Organic oxide - Amine - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Organosulfur compound - Organic oxygen compound - Aromatic heteromonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

MCOLN1 Tchem Mucolipin-1 (2 Activities)

Discover Target: MCOLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 分子量: 336.500 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 336.097 Da
• Monoisotopic Mass: 336.097 Da
• Topological Polar Surface Area: 86.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 457.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1