≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
MKC-3946 MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.
Targets
IRE1α endoribonuclease
In vitro
MKC-3946 triggers modest growth inhibition in MM cell lines, without toxicity in normal mononuclear cells. Importantly, it significantly enhances cytotoxicity induced by bortezomib or 17-AAG, even in the presence of bone marrow stromal cells or exogenous IL-6. Both bortezomib and 17-AAG induce ER stress, evidenced by induction of XBP1s, which is blocked by MKC-3946. Apoptosis induced by these agents is enhanced by MKC-3946, associated with increased CHOP. MKC-3946 treatment does not inhibit IRE1α kinase function or binding of activated IRE1α to TRAF2 and downstream JNK signaling.
In vivo
MKC-3946 inhibits XBP1 splicing in a model of ER stress associated with significant growth inhibition of MM cells.
Cell Research(from reference)
Cell lines：RPMI 8226 cells
Concentrations：2.5, 5, 10 μM
Incubation Time：3 hours
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| 分類 | Naphthalenes |
| Subclass | Naphthols and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Naphthols and derivatives |
| Alternative Parents | Thiophene carboxamides 2-heteroaryl carboxamides N-methylpiperazines Aryl-aldehydes 2,5-disubstituted thiophenes 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Tertiary carboxylic acid amides Heteroaromatic compounds Trialkylamines Amino acids and derivatives Azacyclic compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | 2-naphthol - 2-heteroaryl carboxamide - Thiophene carboxamide - Thiophene carboxylic acid or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Aryl-aldehyde - Phenol - N-methylpiperazine - 2,5-disubstituted thiophene - N-alkylpiperazine - 1,4-diazinane - Piperazine - Tertiary carboxylic acid amide - Thiophene - Heteroaromatic compound - Vinylogous acid - Tertiary amine - Tertiary aliphatic amine - Amino acid or derivatives - Carboxamide group - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Aldehyde - Organic oxygen compound - Organooxygen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | 日付 | 商品 |
|---|---|---|---|
 J2218229 | Certificate of Analysis | Aug 15, 2025 | M413961 |
| J2218228 | Certificate of Analysis | Aug 15, 2025 | M413961 |
| J2218227 | Certificate of Analysis | Aug 15, 2025 | M413961 |
| C2527341 | Certificate of Analysis | Jul 01, 2022 | M413961 |
| 溶解度 | Solubility (25°C) In vitro DMSO: 38 mg/mL (99.87 mM); Ethanol: 3 mg/mL (7.88 mM); Water: Insoluble; |
|---|---|
| DMSO（mg / mL） 最大溶解度 | 38 |
| DMSO（mM） 最大溶解度 | 99.87909373 |
| 水（mg / mL） 最大溶解度 | ＜1 |
| 分子量 | 380.500 g/mol |
| XLogP3 | 3.800 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 380.119 Da |
| Monoisotopic Mass | 380.119 Da |
| Topological Polar Surface Area | 89.100 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 552.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
