ML401 - Moligand™,10mM in DMSO , CAS No.1597489-14-9

CAS: 1597489-14-9 Cat. No.: M655581 分子式: C₂₀H₂₀BrClN₂O 分子量: 419.7 PubChem CID: 73169083

グレード＆純度 Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicity

In Vitro

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML401 shows very good stability in both human plasma and mouse plasma . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 1.03 nM (EBI2)

仕様

仕様と純度

Moligand™,10mM in DMSO

生化学的・生理学的メカニズム

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicity.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ANTAGONIST

名前と識別子

異性体SMILES

C1CN(CCN1CC2=CC=C(C=C2)Cl)C(=O)/C=C/C3=CC=C(C=C3)Br

PubChem CID

73169083

分子量

419.7

関連ターゲット（人間）

GPR183 Tchem G-protein coupled receptor 183 (2 Activities)

Discover Target: GPR183

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1597489-14-9, the molecular formula is C20H20BrClN2O, and the molecular weight is 419.7 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.