MLT-231 - ≥99% , CAS No.M659289

CAS: M659289 Cat. No.: M659289 分子式: C₁₉H₁₉ClF₃N₇O₂ 分子量: 469.85

グレード＆純度 ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

MLT-231 is a potent, highly selective allosteric MALT1 Inhibitor with an IC 50 of 9 nM. MLT-231 specifically prevents endogenous BCL10 cleavage with IC 50 of 160 nM. MLT-231 shows antitumor activity in an ABC-DLBCL type xenograft model in mouse.

Appearance:Solid

In Vitro:MLT-231 (19.5-10000 nM) inhibits the proliferation of OCI-Ly3 cells. MLT-231 (50-5000 nM; 24 hours) leads to accumulation of the uncleaved form of its substrates CYLD, BCL10, and RELB while expression of the NF-κB target gene IRF4 is suppressed. MCE

In Vivo:MLT-231 (10-100mg/kg; p.o.; bid schedule for 2 weeks) displays in vivo efficacy in the ABC-DLBCL xenograft model. MLT-231 (1mg/kg; i.v.; BALB/c mice) treatment shows the CL, t 1/2 , and V ss are 11 mL/min/kg, 1.9 hours, and 1.5 L/kg, respectively.

Biological Activity:MLT-231 is a potent, highly selective allosteric MALT1 Inhibitor with an IC 50 of 9 nM. MLT-231 specifically prevents endogenous BCL10 cleavage with IC 50 of 160 nM. MLT-231 shows antitumor activity in an ABC-DLBCL type xenograft model in mouse.

仕様

仕様と純度

≥99%

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

カノニカル・スマイル

O=C(NC1=C(N2[C@@H](C)COC[C@@H]2C)N3C(N=C1)=CC(Cl)=N3)NC4=CC=NC(C(F)(F)F)=C4

分子量

469.85

化学的性質と物理的性質

• 溶解度: DMSO : 110 mg/mL (234.12 mM; Need ultrasonic)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is M659289, the molecular formula is C19H19ClF3N7O2, and the molecular weight is 469.85 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.