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MM-401 TFA - ≥99% , CAS No.1442106-11-7
注文可能
グレード＆純度 ≥99%
Storage
Protected from light,Store at -80°C
Shipped In
Dry ice packs + Cold packs
このグレードを選ぶ理由
≥99% ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。
保管・配送
Protected from light,Store at -80°C Dry ice packs + Cold packs に出荷。正確な仕様については、ロット固有の COA をご確認ください。
品質書類
SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。
文献的裏付け
クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。
概要
MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity ( IC 50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia
In Vitro
MM-401 maintains high binding affinity to WDR5 with a K i value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC 50 value of 0.9 nM. MM-401 is able to specifically inhibit MLL1 activity (IC 50 value of 0.32µM) by blocking MLL1-WDR5 interaction and thus the complex assembly. MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells. MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion. MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Specifically induced apoptosis of MLL-AF9 cells. Cell Cycle AnalysisCell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner. RT-PCRCell Line: MLL-AF9 cells Concentration: 20 μM Incubation Time: 48 h Result: Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.
Form:Solid
IC50& Target:Ki: < 1 nM (WDR5),IC50: 0.9 nM (WDR5-MLL1 interaction), 0.32 µM (MLL1)
仕様
仕様と純度
≥99%
生化学的・生理学的メカニズム
MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity ( IC 50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL le
保管条件
Protected from light,Store at -80°C
入荷
Dry ice packs + Cold packs
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
純度
≥99%
名前と識別子
分子量
700.75
ドキュメント
📋 安全データシート（SDS）
危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。
<<<<<<< HEAD SDS をダウンロード → ======= SDS をダウンロード → >>>>>>> release248-p3詳細データ
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
化学的性質と物理的性質
| 溶解度 | DMSO : 100 mg/mL (142.70 mM; ultrasonic and warming and heat to 60°C) |
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