MMP13-IN-2 - ≥99% , CAS No.935759-55-0

CAS: 935759-55-0 Cat. No.: M647635 分子式: C₂₄H₁₉FN₆O₄S 分子量: 506.51

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 ( IC 50 =0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1 , 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research

In Vitro

In a bovine nasal cartilage (BNC) assay, the chondrocyte-mediated degradation of cartilage was studied using bovine nasal cartilage slices cultured for up to 14 days. MMP13-IN-2 (0.01-1 µM) is effective at preventing the IL-1/OSM induced in vitro degradation of BNC (-17.6%, 48.4% and 70.8% inhibition of cartilage degradation, respectively).. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MMP13-IN-2 (oral gavage; 1 mg/kg) shows the best combination of CYP3A4 inhibition risk and oral exposure at a dose of 1 mg/kg in rats and mice (F% = 33 and 38, respectively) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:MMP-13 0.036 nM (IC 50 ) MMP-2 180 nM (IC 50 ) MMP-3 1100 nM (IC 50 )

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 ( IC 50 =0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1 , 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to bloc

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

分子量

506.51

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (197.43 mM; ultrasonic and warming and heat to 60°C)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 935759-55-0, the molecular formula is C24H19FN6O4S, and the molecular weight is 506.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.