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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC 50 of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC 50 of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice.
| Canonical Smiles | CCCCCC(C1C2CC3=C(COC(=C3)C=CC)C(=O)C2(OC1=O)C)O |
|---|---|
| IUPAC Name | (3S,3aR,9aR)-3-[(1S)-1-hydroxyhexyl]-9a-methyl-6-[(E)-prop-1-enyl]-3,3a,4,8-tetrahydrofuro[3,2-g]isochromene-2,9-dione |
| InChIKey | GNZJIIUXMNGZCY-IRHWDSGUSA-N |
| INCHI | 1S/C21H28O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10,16-18,22H,4,6-7,9,11-12H2,1-3H3/b8-5+/t16-,17+,18+,21-/m1/s1 |
| Isomeric SMILES | CCCCC[C@@H]([C@@H]1[C@H]2CC3=C(COC(=C3)/C=C/C)C(=O)[C@@]2(OC1=O)C)O |
| PubChem CID | 46913629 |
| MeSH Entry Terms | monascuspiloin |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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