Mps1-IN-2 - Moligand™,10mM in DMSO , CAS No.1228817-38-6

CAS: 1228817-38-6 Cat. No.: M655150 分子式: C₂₆H₃₆N₆O₃ 分子量: 480.60 PubChem CID: 44968267

グレード＆純度 Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC 50 and a K d of 145 nM and 12 nM for Mps1 and a K d of 61 nM for Plk1 .

In Vitro

Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC 50 and a K d of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with K d s of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Mps1 12 nM (Kd) GAK 140 nM (Kd) PLK1 61 nM (Kd) PLK3 1600 nM (Kd) PLK4 3100 nM (Kd) STK33 5000 nM (Kd)

仕様

仕様と純度

Moligand™,10mM in DMSO

生化学的・生理学的メカニズム

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC 50 and a K d of 145 nM and 12 nM for Mps1 and a K d of 61 nM for Plk1 .

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

名前と識別子

異性体SMILES

CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(CCC(=O)N4C)C5CCCC5

PubChem CID

44968267

分子量

480.60

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1228817-38-6, the molecular formula is C26H36N6O3, and the molecular weight is 480.60 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.