MR-L2 - 10mM in DMSO , CAS No.2374703-19-0

CAS: 2374703-19-0 Cat. No.: M656830 分子式: C₁₉H₁₆Cl₃FN₄O 分子量: 441.71 PubChem CID: 138911347

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4) , activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC 50 of 1.2 µM

In Vitro

MR-L2 (0.3-10 μM; 1 h) significantly suppresses cAMP elevation and cysts formation in MDCK cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Madin-Darby Canine Kidney (MDCK) cell line Concentration: 0.3, 1, 3 and 10 μM Incubation Time: 1 hour Result: Suppressed cAMP elevation but not enhanced cAMP excretion in MDCK cells. Suppressed cysts formation in MDCK cells with an EC 50 value of 1.2 µM. Suppressed the number of cysts formation in 3D culture for both unstimulated and Vasotocin-treated culture condition while showed no effect on cell viability.

IC50& Target:PDE4

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4) , activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ACTIVATOR

名前と識別子

• PubChem CID: 138911347
• 分子量: 441.71

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2374703-19-0, the molecular formula is C19H16Cl3FN4O, and the molecular weight is 441.71 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.