MRT-81 - 10mM in DMSO , CAS No.1263132-08-6

CAS: 1263132-08-6 Cat. No.: M656891 分子式: C₃₁H₂₉N₃O₅S 分子量: 555.64

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

MRT-81 is a potent antagonist of human and rodent smoothened ( Smo ) receptors, with an IC 50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer

In Vitro

MRT-81 inbihits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatasepositive osteoblasts induced by the Smo agonist SAG (0.1 μM), with an IC 50 value of 64 nM. MRT-81 (1-1000 nM) is a potent antagonist of SAG (0.01 μM)-induced proliferation of rat granule cell precursors (GCPs) with an IC 50 less than 10 nM. MRT-81 (0, 0.1, 1, 10, 30, 100, 300, 1000 nM; 2 h; 37 °C) blocks BODIPY-cyclopamine (5 nM) binding to hSmo in a dose-dependent manner with an IC 50 of 63 nM in HEK-hSmo cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 41 nM (Shh-light2 cells Smo receptors)

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

MRT-81 is a potent antagonist of human and rodent smoothened ( Smo ) receptors, with an IC 50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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名前と識別子

• 分子量: 555.64