MRT68921 HCl - ≥98% , CAS No.1190379-70-4(freebase)

CAS: 1190379-70-4(freebase) Cat. No.: M413884 分子式: C₂₅H₃₄N₆O·xHCl 分子量: 434.6（freebase）

GRADE & PURITY ≥98%

Synonyms

N-​[3-​[[5-​cyclopropyl-​2-​[(1,​2,​3,​4-​tetrahydro-​2-​methyl-​6-​isoquinolinyl)​amino]​-​4-​pyrimidinyl]​amino]​propyl]​-Cyclobutanecarboxamide hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Information

MRT68921 HCl MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

Targets

ULK2 (Cell-free assay); ULK1 (Cell-free assay) 1.1 nM; 2.9 nM

In vitro

MRT68921 specifically disrupts autophagosome maturation and thus blocks autophagic flux through ULK1 inhibition.

Cell Research(from reference)

Cell lines：MEFs and 293T cells 

Concentrations：1 μM 

Incubation Time：1 h 

Specifications

同義語

N-​[3-​[[5-​cyclopropyl-​2-​[(1,​2,​3,​4-​tetrahydro-​2-​methyl-​6-​isoquinolinyl)​amino]​-​4-​pyrimidinyl]​amino]​propyl]​-Cyclobutanecarboxamide hydrochloride

仕様と純度

≥98%

生化学的・生理学的メカニズム

MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.Mrt68921 hydrochloride has cytotoxicity and kills cancer cells by acting on oxidative stress signals. It is an effective tumor therapeutic drug. M

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

製品の性質

ALogP

4.644

hba_count

3

HBD数

3

回転可能な結合

9

名前と識別子

カノニカル・スマイル

CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C4CC4)C(=N3)NCCCNC(=O)C5CCC5

代替CAS番号

2080306-21-2

分子量

434.6（freebase）

Reaxy-Rn

19608518

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19608518&ln=

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 10 mg/mL warmed with 50ºC Water: bath Water: Insoluble; Ethanol: Insoluble
• DMSO（mg / mL） 最大溶解度: 10
• DMSO（mM） 最大溶解度: 23.010723
• 水（mg / mL） 最大溶解度: ＜1

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1190379-70-4(freebase), the molecular formula is C25H34N6O·xHCl, and the molecular weight is 434.6（freebase） g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.