MS140 - 10mM in DMSO , CAS No.2229974-83-6

CAS: 2229974-83-6 Cat. No.: M422678 分子式: C₃₉H₄₀N₁₀O₇ 分子量: 760.8

GRADE & PURITY 10mM in DMSO

Synonyms

1H-​Isoindole-​1,​3(2H)​-​dione,4-​[[2-​[4-​[6-​[(6-​acetyl-​8-​cyclopentyl-​7,​8-​dihydro-​5-​methyl-​7-​oxopyrido[2,​3-​d]​pyrimidin-​2-​yl)​amino]​-​3-​pyridinyl]​-​1-​piperazinyl]​-​2-​oxoethyl]​amino]​-​2-​(2,​6-​dioxo-​3-​piperidinyl)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Application

PROTAC

概要

Information

MS140 MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).

Targets

CDK4 ; CDK6

In vitro

MS140 potently and selectively both inhibits and degrades CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4–CRBN–E3 ubiquitin complex.

In vivo

Treatment of mice with MS140 promoted degradation of CDK4/6 kinases and suppression of RB–E2F output in JeKo-1 (MCL) and Colo25 (colorectal carcinoma) xenografts in vivo.

Cell Research(from reference)

Cell lines：Colo205 cells 

Concentrations：0.3\u2009μM 

Incubation Time：5\u2009h 

Specifications

同義語

1H-​Isoindole-​1,​3(2H)​-​dione,4-​[[2-​[4-​[6-​[(6-​acetyl-​8-​cyclopentyl-​7,​8-​dihydro-​5-​methyl-​7-​oxopyrido[2,​3-​d]​pyrimidin-​2-​yl)​amino]​-​3-​pyridinyl]​-​1-​piperazinyl]​-​2-​oxoethyl]​amino]​-​2-​(2,​6-​dioxo-​3-​piperidinyl)​-

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

名前と識別子

• パブケム・シド: 528765569
• カノニカル・スマイル: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C
• IUPAC Name: 4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]-2-oxoethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• InChIKey: IWFNIKIERKCKFZ-UHFFFAOYSA-N
• INCHI: 1S/C39H40N10O7/c1-21-26-19-42-39(45-34(26)48(23-6-3-4-7-23)37(55)32(21)22(2)50)43-29-12-10-24(18-41-29)46-14-16-47(17-15-46)31(52)20-40-27-9-5-8-25-33(27)38(56)49(36(25)54)28-11-13-30(51)44-35(28)53/h5,8-10,12,18-19,23,28,40H,3-4,6-7,11,13-17,20H2,1-2H3,(H,44,51,53)(H,41,42,43,45)
• 分子量: 760.8
• Reaxy-Rn: 33062994
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33062994&ln=

化学的性質と物理的性質

• 分子量: 760.800 g/mol
• XLogP3: 2.200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 9
• Exact Mass: 760.308 Da
• Monoisotopic Mass: 760.308 Da
• Topological Polar Surface Area: 207.000 Ų
• Heavy Atom Count: 56
• Formal Charge: 0
• Complexity: 1660.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1