MS8815 - 10mM in DMSO , CAS No.2855085-25-3

CAS: 2855085-25-3 Cat. No.: M655087 分子式: C₆₅H₈₇N₉O₈S 分子量: 1154.51

グレード＆純度 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC 50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC)

In Vitro

MS8815 shows potency in inhibiting the EZH2 and EZH1 methyltransferase activity with IC 50 values of 8.6 nM and 62 nM, respectively. MS8815 (0.1-1 μM) degrades EZH2 with a DC 50 value of 140 nM in MDA-MB-453 cells. MS8815 (1 μM; 48 h) induces robust EZH2 degradation in a concentration-, time-, and proteasome-dependent manner in TNBC cells. MS8815 (0.1-10 μM; 5 days) effectively suppresses the cell growth in multiple TNBC cell lines and primary patient TNBC cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MDA-MB-453 cells and BT549 cells Concentration: 0.3, 3 μM; 1μM Incubation Time: 48 h; 24 h Result: Induced nearly complete degradation of EZH2 and exhibited the most robust degradation at 0.3 μM. Induced EZH2 degradation in a time-and concentration-dependent manner. Induced EZH2 degradation through the UPS. Cell Proliferation AssayCell Line: BT549, MDA-MB-468, SUM159 and MDA-MB-453 cells Concentration: 0.1-10 μM Incubation Time: 5 days Result: Showed superior cellular growth inhibition activity in a panel of TNBC cells.

IC50& Target:IC50: 8.6 nM (EZH2),62 nM (EZH1),DC50: 140 nM (EZH2 in MDA-MB-453 cells)

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC 50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC).

保管条件

Desiccated,Store at -80°C

入荷

Dry ice packs + Cold packs

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アクションタイプ

INHIBITOR

名前と識別子

分子量

1154.51

よくある質問

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2855085-25-3, the molecular formula is C65H87N9O8S, and the molecular weight is 1154.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.