Name: MSX-122 - 10mM in DMSO , C-X-C chemokine receptor type 4 antagonist, CAS No.897657-95-3, C-X-C chemokine receptor type 4 antagonist
SKU: M426733
Availability: InStock

MSX-122 - 10mM in DMSO , C-X-C chemokine receptor type 4 antagonist, CAS No.897657-95-3, C-X-C chemokine receptor type 4 antagonist

CAS: 897657-95-3 Cat. No.: M426733 分子式: C₁₆H₁₆N₆ 分子量: 292.34

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MSX-122 - 10mM in DMSO CAS No(897657-95-3) by Aladdin Scientific

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注文可能

GRADE & PURITY 10mM in DMSO

Synonyms

Q27264343 | XKB65795 | UNII-69D634Q702 | BDBM194510 | DB12715 | N,N'-(1,4-phenylenebis(methylene))bis(pyrimidin-2-amine) | FT-0699836 | AKOS030526974 | A861074 | EX-A784 | 69D634Q702 | BCP16282 | MSX 122 [WHO-DD] | MS-24180 | SB19805 | MSX 122 | MSX122 |

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要 Specifications 製品の性質名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質ソリューション計算機レビュー

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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

Information

MSX-122 is a novel small molecule and partialCXCR4antagonist (IC50~10 nM).

Targets

CXCR4 ~10 nM

In vitro

MSX-122 is also incapable of blocking the binding of 125I-labeled CXCL12 to CXCR4. MSX-122 appears to be insufficiently large to block all binding sites between CXCR4 and CXCL12. MSX-122 blocks certain CXCR4 functions via binding to the CXCL12-binding site and interfering with CXCR4/CXCL12-mediated signaling. MSX-122 can intervene in the Gαi-signaling pathway (cAMP modulation), but not the Gq-pathway (calcium flux).

In vivo

MSX-122 blocks bleomycin-induced lung fibrosis involving chemotaxis and homing of CXCR4-positive mesenchymal progenitor cells into the lungs. MSX-122 exhibits anti-inflammatory activity in a carrageenan-induced paw edema model. MSX-122 blocks lung metastasis of breast cancer and SCCHN, and liver metastasis of uveal melanoma in vivo.

Cell Research(from reference)

Cell lines：MDA-MB-231 cells

Concentrations：1, 10, 100, and 1000 nM

Incubation Time：15 mins

Specifications

同義語

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

MSX-122 is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ANTAGONIST

作用メカニズム

C-X-C chemokine receptor type 4 antagonist

製品の性質

ALogP	2.1

名前と識別子

パブケム・シド	528765576
カノニカル・スマイル	C1=CN=C(N=C1)NCC2=CC=C(C=C2)CNC3=NC=CC=N3
IUPAC Name	N-[[4-[(pyrimidin-2-ylamino)methyl]phenyl]methyl]pyrimidin-2-amine
InChIKey	PXZXYRKDDXKDTK-UHFFFAOYSA-N
INCHI	1S/C16H16N6/c1-7-17-15(18-8-1)21-11-13-3-5-14(6-4-13)12-22-16-19-9-2-10-20-16/h1-10H,11-12H2,(H,17,18,21)(H,19,20,22)
異性体SMILES	C1=CN=C(N=C1)NCC2=CC=C(C=C2)CNC3=NC=CC=N3
分子量	292.34
Reaxy-Rn	11289117
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11289117&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - 分類 Benzene and substituted derivatives
    - Subclass Benzylamines

Kingdom	Organic compounds
Superclass	Benzenoids
分類	Benzene and substituted derivatives
Subclass	Benzylamines
Intermediate Tree Nodes	Not available
Direct Parent	Benzylamines
Alternative Parents	Aminopyrimidines and derivatives Heteroaromatic compounds Azacyclic compounds Hydrocarbon derivatives Amines
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzylamine - Aminopyrimidine - Pyrimidine - Heteroaromatic compound - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Amine - Aromatic heteromonocyclic compound
説明	This compound belongs to the class of organic compounds known as benzylamines. These are organic compounds containing benzylamine, which consists of a benzene group attached to an amine group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

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レビュー

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分子量	292.340 g/mol
XLogP3	2.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	292.144 Da
Monoisotopic Mass	292.144 Da
Topological Polar Surface Area	75.600 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	263.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1