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MTX-23 , CAS No.2488296-74-6
注文可能
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
Application
PROTAC
Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
概要
MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.
In Vitro
MTX-23 (compound 16; 0-20 μM; 4 d; 22Rvl cells) inhibits cell growth in dose-dependent manner. MTX-23 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels. MTX-23 (1 μM; 0-48 h; 22Rvl cells) induces apoptosis and increases annexin-V staining. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: 22Rvl cells Concentration: 0-20 μM Incubation Time: 4 days Result: Reduced the cell count by less than 50 percent. Apoptosis AnalysisCell Line: 22Rvl cells Concentration: 1 μM Incubation Time: 0-48 h Result: Induced cell apoptosis in 22Rvl cells. Western Blot AnalysisCell Line: 22Rvl cells Concentration: 10 μM Incubation Time: 4 days Result: Reduced AR-V7 protein levels.
In Vivo
MTX-23 (compound 16; 2.5 mg/mL; intratumor injection) inhibits tumor growth in nu/nu mice with 22Rvl-Enz R tumor xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: nu/nu mice with 22Rvl-Enz R tumor xenografts Dosage: 2.5 mg/mL Administration: intratumor injection Result: Inhibited tumor growth in nu/nu mice with 22Rvl-Enz R tumor xenografts.
Form:Solid
Specifications
生化学的・生理学的メカニズム
MTX-23 is an AR-based PROTAC . MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.
保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
名前と識別子
| 分子量 | 882.05 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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よくある質問
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 2488296-74-6, the molecular formula is C43H53F2N7O7S2, and the molecular weight is 882.05 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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