Nabumetone - Moligand™, 10mM in DMSO , Cyclooxygenase-2 inhibitor, CAS No.42924-53-8, Cyclooxygenase-2 inhibitor

CAS: 42924-53-8 Cat. No.: N408414 分子式: C₁₅H₁₆O₂ 分子量: 228.29 EC番号: 641-917-1

グレード＆純度 Moligand™, 10mM in DMSO

Synonyms

BRL-14777 | 2-Butanone, 4-(6-methoxy-2-naphthalenyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Nabumetone Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX .
In vitro

Nabumetone is a nonsteroidal anti-inflammatory prodrug. Nabumetone itself is non-acidic and, following absorption, it undergoes extensive first-pass metabolism to form the main circulating active metabolite (6-MNA) which is a much more potent inhibitor of preferentially COX-2.

In vivo

Nabumetone displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs. Its activity in these tests is greater than that of aspirin but less than that of naproxen and indomethacin. In the cotton pellet-induced granuloma model in the rat, Nabumetone is active and produces no signs of toxicity at doses much greater than the lowest effective dose, unlike aspirin, naproxen or indomethacin. Nabumetone is also active in the adjuvant-induced arthritis test in rats. In contrast to aspirin, indomethacin and naproxen, Nabumetone is well tolerated by the stomach of fasted rats at doses in excess of those with anti-inflammatory activity.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

仕様

同義語

BRL-14777 | 2-Butanone, 4-(6-methoxy-2-naphthalenyl)-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Cyclooxygenase-2 inhibitor

製品の性質

ALogP

3.1

名前と識別子

異性体SMILES

CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC

分子量

228.29

Reaxy-Rn

2103472

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2103472&ln=

関連ターゲット（人間）

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A (1 Activities)

Discover Target: MAOA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 融点（°C）: 76-78°C

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 42924-53-8, the molecular formula is C15H16O2, and the molecular weight is 228.29 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.