Naringin - Moligand™, ≥90%, from citrus fruit , CAS No.10236-47-2

Name: Naringin - Moligand™, ≥90%, from citrus fruit , CAS No.10236-47-2
Brand: Aladdin Scientific
SKU: N431264
Availability: InStock

CAS: 10236-47-2 Cat. No.: N431264 分子式: C₂₇H₃₂O₁₄ 分子量: 580.53 Beilstein Registry Number: 102012 EC番号: 233-566-4

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Naringin - Moligand™, ≥90%, from citrus fruit CAS No(10236-47-2) by Aladdin Scientific

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注文可能

グレード＆純度 Moligand™ ? ≥90% from citrus fruit

Synonyms

(2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside | (2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-betaD-glucopyranos

Storage

Room temperature

概要仕様名前と識別子ドキュメント詳細データ Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質よくある質問と記事 Citations of This Product ソリューション計算機レビュー

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このグレードを選ぶ理由

Moligand™, ≥90%, from citrus fruit Moligand™ ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。

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保管・配送

Room temperature に出荷。正確な仕様については、ロット固有の COA をご確認ください。

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品質書類

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文献的裏付け

クロマトグラフィー、有機合成、クロスカップリング反応に関する 83 件の査読済み論文で引用されています。

概要

Naringin is a flavanone glycoside.

Application

Naringin has been used in a study to assess aldosterone production by a human adrenocortical cell line. Long-term naringin consumption reverses a glucose uptake defect and can be used to improve cognitive deficits of Alzheimer′s disease.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N1376.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit .com/metlin.

仕様

同義語

仕様と純度

Moligand™, ≥90%, from citrus fruit

生化学的・生理学的メカニズム

Naringin, a flavanoid in grapefruit and other citrus fruits, potently inhibits intestinal organic anion-transporting polypeptide 1A2 (OATP1A2). Grapefruit juice thereby reduces bioavailability of many pharmacological agents taken at the same time.

保管条件

Room temperature

等級

Moligand™

純度

≥90%

名前と識別子

カノニカル・スマイル

CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O

IUPAC Name

(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one

InChIKey

DFPMSGMNTNDNHN-ZPHOTFPESA-N

INCHI

1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1

異性体SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O

WGKドイツ

RTECS

QN6340000

分子量

580.53

Beilstein

102012

Reaxy-Rn

25075985

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25075985&ln=

ドキュメント

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詳細データ

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - 分類 Flavonoids
    - Subclass Flavonoid glycosides
      - Level5 Flavonoid O-glycosides
        Level6 Flavonoid-7-O-glycosides

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
分類	Flavonoids
Subclass	Flavonoid glycosides
Intermediate Tree Nodes	Flavonoid O-glycosides
Direct Parent	Flavonoid-7-O-glycosides
Alternative Parents	4'-hydroxyflavonoids 5-hydroxyflavonoids Flavanones Phenolic glycosides Chromones Disaccharides O-glycosyl compounds Aryl alkyl ketones 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Alkyl aryl ethers Oxanes Benzene and substituted derivatives Vinylogous acids Secondary alcohols Polyols Acetals Oxacyclic compounds Primary alcohols Hydrocarbon derivatives Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Flavonoid-7-o-glycoside - 4'-hydroxyflavonoid - 5-hydroxyflavonoid - Flavanone - Hydroxyflavonoid - Flavan - Phenolic glycoside - Chromone - Disaccharide - Glycosyl compound - O-glycosyl compound - Chromane - Benzopyran - 1-benzopyran - Aryl alkyl ketone - Aryl ketone - Phenol - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - 1-hydroxy-4-unsubstituted benzenoid - Oxane - Benzenoid - Monocyclic benzene moiety - Vinylogous acid - Secondary alcohol - Ketone - Polyol - Acetal - Organoheterocyclic compound - Oxacycle - Ether - Primary alcohol - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Alcohol - Organooxygen compound - Aromatic heteropolycyclic compound
説明	This compound belongs to the class of organic compounds known as flavonoid-7-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position.
External Descriptors	flavanones
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

関連ターゲット（非人間）

ampC Beta-lactamase AmpC (62480 Activities)

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Abcb1b P-glycoprotein 1 (174 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Salmonella typhimurium (15756 Activities)

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Aggregatibacter actinomycetemcomitans (150 Activities)

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Porphyromonas gingivalis (651 Activities)

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Rattus norvegicus (775804 Activities)

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RAW264.7 (28094 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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BCHE Cholinesterase (8742 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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Slco1a5 Solute carrier organic anion transporter family member 1A5 (48 Activities)

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Thoracic aorta (838 Activities)

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作用メカニズム

証明書（CoA、COO、BSE/TSEと分析図）

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

化学的性質と物理的性質

比旋光度［α］	-84 ° (C=2, EtOH)
融点（°C）	166℃
分子量	580.500 g/mol
XLogP3	-0.500
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	6
Exact Mass	580.179 Da
Monoisotopic Mass	580.179 Da
Topological Polar Surface Area	225.000 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	884.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	11
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

よくある質問と記事

Molecular Basis of Glycosylation Modification and Functional Release in Natural Products

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Natural products glycosylation modification glycosyltransferases glycosidases precursor activation functional release deglycosylation structure-activity relationship

Extraction Methods and Process Selection for Flavonoid Compounds

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

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flavonoid compounds extraction methods solvent extraction ultrasound-assisted extraction microwave-assisted extraction enzyme-assisted extraction supercritical fluid extraction process optimization

Mechanisms by Which Flavonoid Natural Products Regulate the Oxidative Stress-Inflammation Axis

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

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Inflammation Natural products Oxidative Stress Reactive oxygen species Nrf2 NLRP3 flavonoids NF-kappaB

Structural Elucidation of Unknown Flavonoid O-Glycosides—Molecular Formula, Aglycone and Sugar Composition, Linkage Positions, and Anomeric Configurations

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Glucose CID galactose

Citations of This Product

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📚 用途別の引用文献

Organic synthesis — reaction medium34

Other applications31

Extraction & workup solvent35

Spectroscopy sample preparation19

Drug / compound screening11

Chromatography (HPLC / GC / TLC)10

Controlled-release & nanoparticle carrier9

Immune cell assay1

Cytotoxicity screening2

Topical & ophthalmic formulation2

Polymer synthesis & polymerization4

IC50 determination1

Sustained-release matrix1

Electrochemistry & battery electrolyte6

Film coating1

Cell proliferation1

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Naringin - Moligand™, ≥90%, from citrus fruit , CAS No.10236-47-2

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概要

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