ND-336 , CAS No.1807453-83-3

CAS: 1807453-83-3 Cat. No.: N647530 分子式: C₁₆H₁₈ClNO₃S₂ 分子量: 371.90

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2 , MMP-9 , and MMP-14 , with K i s of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound

In Vivo

ND-336 accelerates diabetic wound healing by decreasing inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thus reversing the pathological condition . ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female diabetic db/db mice Dosage: 0.05, 0.025, and 0.01 mg Administration: Topical application; daily for 14 day Result: Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle.

Form:Solid

IC50& Target:MMP-2 85 nM (Ki) MMP-9 150 nM (Ki) MMP-14 120 nM (Ki)

Specifications

生化学的・生理学的メカニズム

ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2 , MMP-9 , and MMP-14 , with K i s of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epi

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

名前と識別子

• 分子量: 371.90