Nefiracetam - 10mM in DMSO , CAS No.77191-36-7

CAS: 77191-36-7 Cat. No.: N408557 分子式: C₁₄H₁₈N₂O₂ 分子量: 246.3 EC番号: 636-080-4

グレード＆純度 10mM in DMSO

Synonyms

DZL 221 | N-​(2,​6-​dimethylphenyl)​-​2-​oxo-1-​pyrrolidineacetamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Nefiracetam Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.
In vitro

Nefiracetam at a concentration of 1 μM increases a long-lasting component of calcium channel currents two-fold without affecting a transient component. Nefiracetam induces a short-term depression of ACh-evoked currents at submicromolar concentrations (0.01–0.1 μM) and a long-term enhancement of the currents at micromolar concentrations (1–10 μM). Nefiracetam interacts with PKA and PKC pathways, which may explain a cellular mechanism for the action of cognition-enhancing agents. Lower (submicromolar) concentrations of the nootropic Nefiracetam reduces ACh-evoked currents to 30% (0.01 μM) and 38% (0.1 μM) of control after a 10-minute treatment. In primary cultures of rat hippocampal neurons, nefiracetam increases the rate of nicotine-sensitive miniature excitatory postsynaptic currents. Nefiracetam induces a long-lasting facilitation of synaptic transmission in both the CA1 area and the dentate gyrus of rat hippocampal slices, and the facilitation is inhibited by α-bungarotoxin and mecamylamine. Nefiracetam enhances activity of nicotinic ACh receptors by interacting with a PKC pathway, thereby increasing glutamate release from presynaptic terminals, and then leading to a sustained facilitation of hippocampal neurotransmission.

In vivo

Nefiracetam administered orally inhibits Ro 5-4864-induced convulsions in EL mice. Nefiracetam also efficiently inhibits Ro 5-4864-induced convulsions in DDY mice at doses higher than 10 mg/kg. Nefiracetam administered daily 1 hour before each training session facilitates the acquisition process of the avoidance response.
Cell Data

cell lines：HCC827, H3255, HCC827 GR, H1975, PC9, PC9 GR, Calu-3, H1819, and Ba/F3

Concentrations：~1 μM

Incubation Time：24 hours - 48 hours

Powder Purity:≥100%

仕様

同義語

DZL 221 | N-​(2,​6-​dimethylphenyl)​-​2-​oxo-1-​pyrrolidineacetamide

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

異性体SMILES

CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O

WGKドイツ

3

RTECS

UX9655650

分子量

246.3

Reaxy-Rn

6848330

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6848330&ln=

化学的性質と物理的性質

• 融点（°C）: 151 °C

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 77191-36-7, the molecular formula is C14H18N2O2, and the molecular weight is 246.3 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.