NF-κΒ activator 2 - ≥98% , CAS No.2375281-44-8

CAS: 2375281-44-8 Cat. No.: N646479 分子式: C₁₆H₁₁FN₂O₃ 分子量: 298.27 PubChem CID: 139434520

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)

In Vitro

NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice . NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and C max (92 ng/mL) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:NF-κB 1.58 μM (EC 50 )

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ACTIVATOR

純度

≥98%

名前と識別子

• カノニカル・スマイル: C1=CC=C(C(=C1)NC2=NC=C(O2)C3=CC(=CC=C3)C(=O)O)F
• IUPAC Name: 3-[2-(2-fluoroanilino)-1,3-oxazol-5-yl]benzoic acid
• InChIKey: VGJMPWREFUKMAD-UHFFFAOYSA-N
• INCHI: 1S/C16H11FN2O3/c17-12-6-1-2-7-13(12)19-16-18-9-14(22-16)10-4-3-5-11(8-10)15(20)21/h1-9H,(H,18,19)(H,20,21)
• 異性体SMILES: C1=CC=C(C(=C1)NC2=NC=C(O2)C3=CC(=CC=C3)C(=O)O)F
• PubChem CID: 139434520
• 分子量: 298.27

作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO : 250 mg/mL (838.17 mM; Need ultrasonic)
• 分子量: 298.270 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 298.075 Da
• Monoisotopic Mass: 298.075 Da
• Topological Polar Surface Area: 75.400 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 396.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1