NHC-diphosphate - ≥98% , CAS No.39023-73-9

CAS: 39023-73-9 Cat. No.: N650859 分子式: C₉H₁₅N₃O₁₂P₂ 分子量: 419.18

GRADE & PURITY ≥98%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

概要

NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) ( HY-125033 ) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV)  and hepatitis C virus (HCV).

In Vitro

Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC. Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP; HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite.. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

NHC-diphosphate is an active phosphorylatedxa0intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) ( HY-125033 ) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent . NHC effectively inhibits the re

保管条件

Protected from light,Store at -20°C,Argon charged

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• 分子量: 419.18

化学的性質と物理的性質

• 溶解度: H2O : 160 mg/mL (381.70 mM; Need ultrasonic)