≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
A far-red (near-infrared) fluorescent contrast agent that permeates the blood-brain barrier (BBB) for highly specific in situ and in vivo staining of amyloid plaques.
NIAD-4 is a far-red (near-infrared) fluorescent contrast agent that permeates the blood-brain barrier (BBB) for highly specific in situ staining of amyloid plaques (10 μM in DMSO/propylene glycol solution; coronal sections of APP mice) and in vivo staining (2 mg/kg intravenous injection in APP mice). Due to its push-pull design and significantly enhanced affinity for the thioflavin T (ThT) site (Ki = 10 nM/NIAD-4 vs 580 nM/ThT), NIAD-4 exhibits a significant red-shift in absorbance (~70 nm) and a 1.3-fold increase in extinction coefficient upon binding to aggregated amyloid-β 1-40 (4.1 μM NIAD-4 and 10 μM amyloid-β in PBS). Excitation light 450-488 nm, emission light 550-650 nm.
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| 分類 | Bi- and oligothiophenes |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Bi- and oligothiophenes |
| Alternative Parents | 2,5-disubstituted thiophenes 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Heteroaromatic compounds Nitriles Organooxygen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Bithiophene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - 2,5-disubstituted thiophene - Monocyclic benzene moiety - Benzenoid - Thiophene - Heteroaromatic compound - Carbonitrile - Nitrile - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxygen compound - Cyanide - Hydrocarbon derivative - Aromatic heteromonocyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as bi- and oligothiophenes. These are organic compounds containing two or more linked thiophene rings. Thiophene is a five-member aromatic ring with one sulfur and four carbon atoms. |
| External Descriptors | Not available |
| 溶解度 | Soluble in water at 20°C |
|---|---|
| 感度 | Light sensitive |
| 融点（°C） | 242-246℃ |
| 分子量 | 334.400 g/mol |
| XLogP3 | 4.400 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 334.023 Da |
| Monoisotopic Mass | 334.023 Da |
| Topological Polar Surface Area | 124.000 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 532.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
C2606678