Name: Nicotinamide - ≥99.5%(HPLC), used for Nicotinamide has been used: to study its effect on the expression of sirtuin 1; in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay; in cell lysis buffer, to serv
Brand: Aladdin Scientific
SKU: N108086
Availability: InStock

概要仕様名前と識別子ドキュメント詳細データ Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質よくある質問と記事 Citations of This Product ソリューション計算機レビュー

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このグレードを選ぶ理由

≥99.5%(HPLC) ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。

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保管・配送

Room temperature,Desiccated Normal に出荷。正確な仕様については、ロット固有の COA をご確認ください。

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品質書類

SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。

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文献的裏付け

クロマトグラフィー、有機合成、クロスカップリング反応に関する 85 件の査読済み論文で引用されています。

概要

Nicotinamide, a form of vitamin B3, is a building block of coenzymes NAD and NADP. Researchers consider it an important signaling molecule, and essential for cell metabolism studies. It has been used in multiple applications and research areas, namely cancer and viral research.

仕様

同義語

仕様と純度

≥99.5%(HPLC)

生化学的・生理学的メカニズム

Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltran

申し込み

Nicotinamide has been used: to study its effect on the expression of sirtuin 1; in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay; in cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to

保管条件

Room temperature,Desiccated

入荷

Normal

アクションタイプ

INHIBITOR

純度

≥99.5%(HPLC)

名前と識別子

パブケム・シド

508814627

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/508814627

カノニカル・スマイル

C1=CC(=CN=C1)C(=O)N

IUPAC Name

pyridine-3-carboxamide

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

INCHI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

異性体SMILES

C1=CC(=CN=C1)C(=O)N

WGKドイツ

RTECS

QS3675000

分子量

122.12

Beilstein

383619

Reaxy-Rn

383619

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=383619&ln=

ドキュメント

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危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。

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✅ 分析証明書（COA）

ロット固有の品質データ。ロット番号を入力して、正確な COA を取得してください。

COA を検索 →

📊 データシート

製品仕様と用途のクイックリファレンス概要。

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🔬 仕様書

このグレードの完全な品質特性と合格基準。

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詳細データ

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 分類 Pyridines and derivatives
    - Subclass Pyridinecarboxylic acids and derivatives
      - Level5 Pyridinecarboxamides
        Level6 Nicotinamides

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
分類	Pyridines and derivatives
Subclass	Pyridinecarboxylic acids and derivatives
Intermediate Tree Nodes	Pyridinecarboxamides
Direct Parent	Nicotinamides
Alternative Parents	Heteroaromatic compounds Primary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Nicotinamide - Heteroaromatic compound - Primary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
説明	This compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.
External Descriptors	a vitamin - an aliphatic amide
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

関連ターゲット（非人間）

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Faah Anandamide amidohydrolase (3907 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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SIR2 NAD-dependent histone deacetylase SIR2 (218 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Leishmania infantum (5912 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Leishmania donovani (89745 Activities)

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Trypanosoma cruzi (99888 Activities)

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Toxoplasma gondii (4585 Activities)

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Rattus norvegicus (775804 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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RAW264.7 (28094 Activities)

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panE Ketopantoate reductase (28 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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HST2 NAD-dependent deacetylase HST2 (97 Activities)

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Plasma (328 Activities)

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SIR2RP1 Putative silent information regulator 2 (21 Activities)

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cobB NAD-dependent protein deacetylase (1 Activities)

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Glra2 Glycine receptor (1745 Activities)

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SARS-CoV-2 (38078 Activities)

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Sarm1 NAD(+) hydrolase SARM1 (23 Activities)

Discover Target: Sarm1

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作用メカニズム

証明書（CoA、COO、BSE/TSEと分析図）

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

25 results found

Lot Number	Certificate Type	日付	商品
F2625417	Certificate of Analysis	Jun 12, 2026	N108086
F2625373	Certificate of Analysis	Jun 12, 2026	N108086
F2625372	Certificate of Analysis	Jun 12, 2026	N108086
D2609444	Certificate of Analysis	Mar 26, 2026	N108086
D2609446	Certificate of Analysis	Mar 26, 2026	N108086
D2609449	Certificate of Analysis	Mar 26, 2026	N108086
H2513597	Certificate of Analysis	Jul 31, 2025	N108086
H2513596	Certificate of Analysis	Jul 31, 2025	N108086
F2527556	Certificate of Analysis	Jun 11, 2025	N108086
F2527558	Certificate of Analysis	Jun 11, 2025	N108086
L2413361	Certificate of Analysis	Nov 28, 2024	N108086
L2413360	Certificate of Analysis	Nov 28, 2024	N108086
E2430541	Certificate of Analysis	May 09, 2024	N108086
E2430540	Certificate of Analysis	May 09, 2024	N108086
I2307450	Certificate of Analysis	Aug 19, 2023	N108086
I2307463	Certificate of Analysis	Aug 19, 2023	N108086
I2208521	Certificate of Analysis	Jul 25, 2022	N108086
I2208522	Certificate of Analysis	Jul 25, 2022	N108086
I2208524	Certificate of Analysis	Jul 25, 2022	N108086
K2419127	Certificate of Analysis	Jul 25, 2022	N108086
K2421136	Certificate of Analysis	Jul 25, 2022	N108086
B2207567	Certificate of Analysis	Jan 08, 2022	N108086
B2207566	Certificate of Analysis	Jan 08, 2022	N108086
B2207552	Certificate of Analysis	Jan 08, 2022	N108086
A2304177	Certificate of Analysis	Jan 08, 2022	N108086

化学的性質と物理的性質

感度	Light sensitive
引火点（°F）	302 °F
引火点（°C）	150 °C
融点（°C）	128-131°C
分子量	122.120 g/mol
XLogP3	-0.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	122.048 Da
Monoisotopic Mass	122.048 Da
Topological Polar Surface Area	56.000 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	114.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

よくある質問と記事

NADH vs NADPH: Homologous coenzymes with distinct functional specialization

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NADH NADPH Coenzymes

Small-Molecule Inhibitors: A Practical Guide for Research Selection — A Minimal Evidence Chain and Scenario-Based Validation Framework (Including a Selection Matrix, Case Cards, and Product Tables 1–4)

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Niacin (Vitamin B3): Structural Features, Metabolic Roles, and Application Landscape

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Pharmaceutical Intermediates Niacin Vitamin B3 Nicotinamide NADP+ Niacin equivalents Nutritional fortification Feed additive

From Piperidine to Pyridine: The “Most Common N-Heterocycle” Shift in FDA Small-Molecule New Drugs (2013–2023) and a Selection Guide (Tables 1–4)

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Vitamins, Coenzymes, and Enzymes: A Metabolic Synergy Network and Its Disease Associations

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REDOX Vitamins Coenzymes Enzymes holoenzymes cofactors group transfer one-carbon metabolism metabolic flux disease associations

NAD (Nicotinamide Adenine Dinucleotide): From a Metabolic Coenzyme to Homeostatic Regulation and Application Targets

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NAD NAD⁺/NADH NADP⁺/NADPH Salvage synthesis Preiss-Handler Denovo synthesis NAD-consuming enzymes Homeostasis Aging

Pyridine Research Selection Roadmap: Structural Features, Reaction Logic, and a Classification Navigator for Reagents/Building Blocks/Reference Standards (Tables 1–6)

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Functional System Overview of Cellular Metabolic Enzymes in Energy Metabolism, Redox, and Signal Transduction

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REDOX NADPH ROS Signal Transduction metabolic enzymes energy metabolism NADH/NAD metabolite signaling flux analysis

Roles of One-Carbon Metabolism Enzymes in Oxidative Stress and Epigenetic Regulation in Cardiovascular Diseases

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Cardiovascular diseases one-carbon metabolism Oxidative Stress homocysteine transsulfuration pathway Nrf2 Folate Cycle Methionine Cycle Epigenetic Regulation S-Adenosylmethionine

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Epigenetic Regulation Acetyl-Group Metabolism Acetyl-Coa Acetyltransferases Deacetylases Pathway Analysis In Vitro Enzymology Central Carbon Metabolism

Noncanonical Functions of Epigenetic Enzymes and Regulation of Mitochondrial Metabolism

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epigenetic enzymes noncanonical functions mitochondrial metabolism mtDNA mitochondrial protein acetylation DNMT1 MOF LSD1

Three-Dimensional Chromatin Architecture Remodeling and Mechanisms of Physiological Aging

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three-dimensional chromatin physiological aging A/B compartments topologically associating domains chromatin loops lamina-associated domains heterochromatin

Understanding Ceramides from the Perspective of the Stratum Corneum Lipid Barrier: Moisturizing and Barrier-Repair Mechanisms, Ingredient Selection, and Formulation Research Considerations

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Nicotinamide Ceramides

Establishment and Evaluation Methods of Diabetic Animal Models

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diabetic animal modeling STZ-induced model alloxan model high-fat diet model HFD+STZ model NOD mice db/db mice ZDF rats

Mechanistic Analysis of Topical Glutathione in Skincare: Cellular Redox Regulation, Skin Delivery Challenges, and SLN-Based Delivery Strategies

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glutathione Cellular redox

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Research on Cell Cycle and DNA Damage Response Mechanisms

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Cell Cycle DNA damage response G1/S checkpoint G2/M checkpoint ATM ATR Chk1 Chk2 CDK genome stability

If the DNA Sequence Remains Unchanged, Why Does Gene Expression Change? Core Mechanisms and Research Methods of Epigenetic Regulation

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DNA Epigenetics gene expression

Analysis of Hydrolyzed Pearl as a Cosmetic Raw Material: Preparation Process, Active Components, and Skincare Formulation Applications

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The Dual-Targeted Skin-Brightening Mechanism of 4-MSK: Inhibiting Melanin Production and Reducing Epidermal Pigment Retention

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Antioxidant Mechanisms, Stability, and Delivery Strategies of Resveratrol in Skincare Research

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Probiotics, Prebiotics, and Postbiotics in Skin Care: Conceptual Distinctions, Mechanisms of Action, and Their Applications in the Care of Dry, Itchy, and Rough Skin

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Potential Mechanisms of Succinic Acid in Acne Care: From Dicarboxylic Acid–Base Equilibria to Metabolic Antagonism Among Skin Microorganisms

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Anti-Photoaging Potential of Artemia Extract: UV-Induced Damage Cascades, HSP70-Related Stress Protection, and GP4G Metabolic Insights

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The Sebum-Regulating Potential of Zinc PCA and Its Relationship with Stratum Corneum Hydration

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Citations of This Product

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📚 用途別の引用文献

Cell proliferation3

Cell viability4

Cytotoxicity screening5

Drug / compound screening15

Extraction & workup solvent23

Organic synthesis — reaction medium33

Controlled-release & nanoparticle carrier8

Electrochemistry & battery electrolyte6

Crystallization & recrystallization13

Chromatography (HPLC / GC / TLC)18

Other applications31

Spectroscopy sample preparation8

Industrial & non-pharma application2

Polymer synthesis & polymerization3

Topical & ophthalmic formulation6

Film coating1

IC50 determination1

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Nicotinamide - ≥99.5%(HPLC), used for Nicotinamide has been used: to study its effect on the expression of sirtuin 1; in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay; in cell lysis buffer, to serv

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関連商品

Nicotinamide - ≥99.5%(HPLC), used for Nicotinamide has been used: to study its effect on the expression of sirtuin 1; in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay; in cell lysis buffer, to serv

保管・配送

品質書類

文献的裏付け

概要

仕様

ドキュメント

📋 安全データシート（SDS）

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